Molecular Genetics of Micrbial Pathogenesis

微生物发病机制的分子遗传学

• 批准号: 03304030
• 负责人: TERAWAKI Yoshiro
• 金额: $ 14.98万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Co-operative Research (A)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03304030/
• 关键词: Bacterial pathogenesis; Toxin gene; Regulation of expression; Activation of toxin; Pathogenic plasmid; Shigella fiexneri; Pseudomonas aeruginosa; Vibrio cholerae; 病原細菌; 病原因子; 病原遺伝子; 調節遺伝子; DNA塩基配列; 病原性プラスミド; 病原性ファージ; 病原細菌学; 病原性の調節; 調節遣伝子

As we prepared a report of this research group in detail in a booklet form, we summarized our results briefly as follows.Microbial pathogenesis of which regulatory mechanism of expression is clarified or is progress.The invasion-diffusion mechanisms of shigella bacilli. The spv virulence of Salmonella choleraesuis. The hemolysin of Vibrio species. The alkaline-protease of Pseudomonas aerug. The perfringolysin of Clostridium perfringens. The pili of Seratia marcescens.microbial pathogemesis of which activation and/or translocation mechanism is clarified.The cytotoxin of Pseudomonas aeruginosa. The hemolysin of Vibrio cholerae.The Vi antigen of Salmonella typhi. Tge hemolysin and leukocidin of Staphylococcus aureus. The hemolysin and bacteriocin of Enterococcus faecalis. The type C and E toxins of Clostridium botulinum.Other Virulence factors.The urease of Helicobacter pylori. The adherence of enteroaggregative Escherichia coli to human mucosa. The autoagglutination of chicken pathogenic Escherichia coli. The fimbiae of porphyromonas gingivalis. The neuraminidase of Bacteroides frag. The serum resistance donated by plasmid R100 TraT product.

当我们以小册子形式详细准备了该研究小组的报告时，我们简要概括了结果，如下所示。阐明了表达的调节机制或进展的microbial发病机理。沙门氏菌霍乱的SPV毒力。颤音物种的血素蛋白。假单胞菌的碱性抑制作用。灌注梭状芽胞杆菌的灌注素。尖锐的马斯科斯菌。阐明了激活和/或易位机制的微生物病变。弧菌霍乱的血素蛋白。沙门氏菌的VI抗原。金黄色葡萄球菌的TGE血解素和白细胞素。粪肠球菌的血素和细菌素。肉毒梭菌的C型和E毒素。其他毒力因子。幽门螺杆菌的尿素酶。肠球形大肠杆菌对人粘膜的依从性。鸡致病性大肠杆菌的自身凝集。斑岩牙龈牙龈的细胞。杀菌剂片段的神经氨酸酶。由质粒R100 TRAT产品捐赠的血清耐药性。

项目成果

Y.Yoshida: "Molecular cloning and characteization of form I antigen genes of Shigella sonnei" J.Gen.Microbiol.137. 867-874 (1991)

Y.Yoshida：“宋内志贺氏菌 I 型抗原基因的分子克隆和表征”J.Gen.Microbiol.137。

A.Naka: "Characterization of two forms of hemagglutinin/protease produced by Vibrio cholerae non-01" FEMS Microbiol.Lett.98. 197-200 (1992)

A.Naka：“霍乱弧菌非 01 产生的两种形式的血凝素/蛋白酶的表征”FEMS Microbiol.Lett.98。

Rahman,A.: "Gamma-hemolysin genes in the same family with lukF and lukS genes in methicillin resistant Stapylococcus aureus." Biosci.Biotech.Biochem.57. 1234-1236 (1993)

Rahman,A.：“γ-溶血素基因与耐甲氧西林金黄色葡萄球菌中的 lukF 和 lukS 基因属于同一家族。”

Moriishi,K.: "Two different types of ADP-ribosyltransferase C3 from Clostridium botulinum type D lysigenized organisms." Infect.Immun.61. 5309-5314 (1993)

Moriishi,K.：“来自 D 型肉毒杆菌裂解生物体的两种不同类型的 ADP-核糖基转移酶 C3。”

Tsuda, M.: "Genetic transformation in Helicobacter Pylori." Micribiol. Immunol.37. 85-89 (1993)

Tsuda, M.：“幽门螺杆菌的基因转化。”