Involvement of Vagal and Sympathetic Afferents on Reflex Renal Nerve Responses to Bile into Canine Pancreatic Duct

迷走神经和交感神经传入对肾神经对胆汁进入犬胰管的反射反应的参与

• 批准号: 02807111
• 负责人: SHIBAMOTO Toshishige
• 金额: $ 0.9万
• 依托单位: Shinshu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1991
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02807111/
• 关键词: Renal nerve activity; Bile; Sympathetic afferents; Vagal afferents; Pancreatic duct; Capsaicin; Bradykinin; 求心性迷走神経; 血圧; 膵炎

This study was designed to study effects of an injection of bile into the Pancreatic duct on mean blood pressure (MBP) and efferent renal nerve activity (RNA) in anesthetized dogs. When 0.5ml/kg of bile was injected into the pancreatic duct, RNA and MBP increased significantly. Peak changes of MBP and RNA were +26 <plus-minus> 8mmHg and +174 <plus-minus> 13%, respectively. When capsaicin (15ug/Kg) and bradykinin (20ug/Kg) were injected into the pancreatic duct, RNA increased significantly so that peak changes in RNA were +86<plus-minus> 11% and +72 <plus-minus> 12% of the control level, respectively. Injection of physiological saline did not cause any significant change in RNA and MBP. However, either after denervation of subdiaphragmatic vagal nerves or after celiac and superior mesenteric sympathectomy, the increase in RNA after injection of bile were significantly smaller than that in the intact animals. Contrastingly, the increased RNA due to capsaicin and bradykinin remained after subdiaphragmatic vagotomy, but disappeared after sympathectomy. In dogs with subdiaphragmatic vagotomy combined with celiac and superior mesenteric sympathectomy, RNA did not change significantly after bile injection. Therefore, these results suggest that injection of bile into the canine pancreatic duct evokes a reflex increase in RNA. which is mediated by both the vagal and sympathetic afferents from the pancreas. However, increases in RNA due to capsaicin and bradykinin are mediated only by sympathetic af

这项研究旨在研究胆汁导管对麻醉犬中平均血压（MBP）和传出的肾神经活性（RNA）的影响。当将0.5ml/kg的胆汁注射到胰管中时，RNA和MBP显着增加。 MBP和RNA的峰值变化分别为+26 <plus-minus> 8mmHg和+174 <plus-minus> 13％。当辣椒素（15盎司/kg）和缓激肽（20ug/kg）被注入胰管导管时，RNA显着增加，因此RNA的峰值变化分别为+86 <plus-minus> 11％和+72 <plus-Minus <plus-Minus> 12％的对照水平的12％。注射生理盐水不会引起RNA和MBP的显着变化。然而，在脑膜副神经神经的去神经或腹腔和肠系膜上性交感神经切除术后，注射胆汁后的RNA的增加明显小于完整动物中的RNA。相比之下，由于肾上腺肌s缩术后，由于辣椒素和缓铁蛋白引起的RNA增加，但在交感神经切除术后消失。在肾上腺副迷走道术结合腹腔和肠系膜上性交感神经切除术的狗中，RNA在胆汁注射后没有显着变化。因此，这些结果表明，将胆汁注射到犬类胰管中会引起RNA的反射增加。这是由胰腺的迷走神经和交感传入介导的。但是，由于辣椒素和心动激肽引起的RNA增加仅由交感神经AF介导

项目成果

Takashi Fujita: "Reflex effcts on renal nerve activity and renal vasculartone during occlusion of superior mesenteic artery in anestheized dogs." J.Autonomic Nervous System. 29. 129-136 (1990)

Takashi Fujita：“麻醉犬肠系膜上动脉闭塞时，反射对肾神经活动和肾血管张力的影响。”

Takashi Juiita: "Reflex effects on renal nerve activity and renal vasculartone during occlusion of superior mesenteic artery in anestheized dogs." J.Autonomic Nervous System. 29. 129-136 (1990)

Takashi Juiita：“麻醉犬肠系膜上动脉闭塞时，反射对肾神经活动和肾血管张力的影响。”

上松 陽光: "自家胆汁の膵管内投与による反射性腎臓交感神経反応" 自律神経. 27. 504-511 (1990)

Yoko Agematsu：“导管内注射自体胆汁引起的肾交感神经反射反应”自主神经。 27. 504-511 (1990)

Harumitsu UEMATSU: "INVOLVEMENT OF VAGAL AND SYMPATHETIC AFFERENTS ON REFLEX RENAL NERVE RESPONSES TO BILE.CAPSAICIN AND BRADYKININ INTO CANINE PANCREATIC DUCT" Jpn.J.Physiol.

Harumitsu UEMATSU：“迷走神经和交感神经传入犬胰管对胆汁、辣椒素和缓激肽的反射性肾神经反应的参与”Jpn.J.Physiol。

Takoshi Fujita: "Reflex effects on renal nerve activity and renal vascular tone during occlusion of sperior mesenteric artery in anesthetized dogs" Journal of the Autonomic Nervous System. 29. 129-136 (1990)

Takashi Fujita：“麻醉狗肠系膜上动脉闭塞期间反射对肾神经活动和肾血管张力的影响”《自主神经系统杂志》。