Investigation on cardiac function during anaphylactic shock

过敏性休克时心功能的调查

基本信息

  • 批准号:
    20592131
  • 负责人:
  • 金额:
    $ 3.16万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2008
  • 资助国家:
    日本
  • 起止时间:
    2008 至 2010
  • 项目状态:
    已结题

项目摘要

The aim of the present study was to determine the effects of anaphylaxis on the left ventricular function in both anesthetized rats and isolated perfused rat hearts. The rats were sensitized with ovalbumin. In anesthetized rats, Emax, an index of cardiac contractility did not decrease but increased at 15 min after antigen injection, suggesting that cardiac contractility did not decrease but increased during sustained hypotension due to systemic anaphylaxis in anesthetized rats. In the study using isolated hearts that were excised from Wister rats sensitized with ovalbumin, and perfused at constant flow with blood in a cross-circulated fashion. Cardiac contractility was evaluated by positive maximum rate of changes in left ventricular pressure (dP/dt_<max>) and end-systolic pressure volume relationships (ESPVRs). After antigen, the coronary vascular resistance increased four times the baseline only transiently after antigen. The dP/dt_<max> decreased transiently along with the decrease in coronary flow. The ESPVRs measured at 10 min after antigen did not change from the baseline. The results from perfused heart experiments suggest that cardiac contractility decreased only transiently along with a decrease in coronary blood flow during cardiac anaphylaxis of isolated blood-perfused rat hearts. In conclusion, cardiac contractility may not decrease, but rather increase later than 10 min after antigen exposure. However, the cardiac anaphylactic reaction itself is accompanied by a transient flow-dependent decrease in cardiac contractility.
本研究的目的是确定在麻醉大鼠和孤立的灌注大鼠心脏中过敏反应对左心室功能的影响。大鼠用椭圆蛋白敏化。在麻醉大鼠中,EMAX,心脏收缩率的指数不会降低,但在抗原注射后15分钟升高,这表明由于麻醉大鼠全身性过敏症而导致的持续性低血压,心脏收缩率没有降低,但增加了。在研究中,使用孤立的心脏,这些心脏是从用椭圆蛋白敏化的北鸟大鼠中切除的,并以跨流通的方式在恒定流动下以恒定的流量进行灌注。通过左心室压力(DP/DT_ <max>)和终端节体压力量关系(ESPVR)的最大变化率评估心脏收缩力。抗原之后,冠状动脉血管耐药性仅在抗原后短暂增加了基线的四倍。 DP/DT_ <max>随着冠状动脉流量的减少而瞬时减少。抗原后10分钟测得的ESPVR没有从基线变化。灌注心脏实验的结果表明,心脏收缩力仅在孤立的血液吞噬大鼠心脏的心脏过敏反应期间暂时降低,而冠状动脉血流降低。总之,心脏收缩性可能不会降低,而是抗原暴露后10分钟的增加。但是,心脏过敏反应本身伴随着心脏收缩性的瞬时流动依赖性降低。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Pulmonary vasoconstrictive and bronchoconstrictive responses to anaphylaxis are weakened via β_2-adrenoceptor activation by endogenous epinephrine in anesthetized rats.
麻醉大鼠中内源性肾上腺素激活β_2-肾上腺素受体,从而减弱了对过敏反应的肺血管收缩和支气管收缩反应。
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    8.8
  • 作者:
    Shibamoto T;Tsutsumi M;Kuda Y;Ohmukai C;Zhang W;Kurata Y;Wei Zhang
  • 通讯作者:
    Wei Zhang
Mast cells are not involved in the ischemia-reperfusion injury in perfused rat liver.
  • DOI:
    10.1016/j.jss.2010.11.900
  • 发表时间:
    2012-05
  • 期刊:
  • 影响因子:
    0
  • 作者:
    T. Shibamoto;M. Tsutsumi;Y. Kuda;Chieko Ohmukai;Wei Zhang;Y. Kurata
  • 通讯作者:
    T. Shibamoto;M. Tsutsumi;Y. Kuda;Chieko Ohmukai;Wei Zhang;Y. Kurata
Pulmonary vasoconstrictive and bronchoconstrictive responses to anaphylaxis are weakened via β 2-adrenoceptor activation by endogenous epinephrine in anesthetized rats.
麻醉大鼠中内源性肾上腺素激活β2-肾上腺素受体,从而减弱了对过敏反应的肺血管收缩和支气管收缩反应。
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Zhang W;Shibamoto T;Kuda Y;Ohmukai C;Kurata Y
  • 通讯作者:
    Kurata Y
血液交叉灌流系を用いた心アナフィラキシーの病態解明:心収縮性と冠血流への影響
使用血液交叉灌注系统阐明心脏过敏反应的病理学:对心肌收缩力和冠状动脉血流的影响
  • DOI:
  • 发表时间:
    2011
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shibamoto T;Tsutsumi M;Kuda Y;Ohmukai C;Zhang W;Kurata Y;Wei Zhang;Chiaki Kamikado;Toshishige Shibamoto;倉田康孝(芝本利重)
  • 通讯作者:
    倉田康孝(芝本利重)
ラット血液交差灌流心臓における心アナフィラキシーの検討
大鼠血液交叉灌注心脏心脏过敏反应的研究
  • DOI:
  • 发表时间:
    2010
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shibamoto T;Tsutsumi M;Kuda Y;Ohmukai C;Zhang W;Kurata Y;Wei Zhang;Chiaki Kamikado;Toshishige Shibamoto;倉田康孝(芝本利重);九田裕一(芝本利重)
  • 通讯作者:
    九田裕一(芝本利重)
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SHIBAMOTO Toshishige其他文献

SHIBAMOTO Toshishige的其他文献

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{{ truncateString('SHIBAMOTO Toshishige', 18)}}的其他基金

Application of noninvasive thermography to detect the biphasic anaphylaxis in the rat
应用无创热成像检测大鼠双相过敏反应
  • 批准号:
    19K09445
  • 财政年份:
    2019
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The role of angiopoietin-2 in anaphylactic shock
血管生成素2在过敏性休克中的作用
  • 批准号:
    16K11428
  • 财政年份:
    2016
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Systematic study on brain circulation during anaphylactic shock
过敏性休克时脑循环的系统研究
  • 批准号:
    25462839
  • 财政年份:
    2013
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Hepatic microvascular pressure during circulatory shock
循环休克期间的肝微血管压力
  • 批准号:
    18591730
  • 财政年份:
    2006
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Integrative study on hepatic anaphylaxis
肝脏过敏反应的综合研究
  • 批准号:
    15591665
  • 财政年份:
    2003
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Vascular occlusion methods analyze hepatic hemodynamics in acute and chronic liver injury
血管闭塞方法分析急慢性肝损伤中的肝脏血流动力学
  • 批准号:
    10557138
  • 财政年份:
    1998
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
The vascular occlusion methods for determination of hepatic vasoconstriction sites
血管闭塞法测定肝血管收缩部位
  • 批准号:
    08671723
  • 财政年份:
    1996
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The role of sympathetic nervous system in the genesis of pulmonary edema
交感神经系统在肺水肿发生中的作用
  • 批准号:
    05454420
  • 财政年份:
    1993
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (B)
Involvement of Vagal and Sympathetic Afferents on Reflex Renal Nerve Responses to Bile into Canine Pancreatic Duct
迷走神经和交感神经传入对肾神经对胆汁进入犬胰管的反射反应的参与
  • 批准号:
    02807111
  • 财政年份:
    1989
  • 资助金额:
    $ 3.16万
  • 项目类别:
    Grant-in-Aid for General Scientific Research (C)

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Incorporating hepatic cell function into lung ex vivo lung perfusion for transplant preservation
将肝细胞功能纳入肺离体肺灌注以保存移植物
  • 批准号:
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Heart Rate Variability, Cognitive Performance, and Alzheimer Disease-related Pathology in the Multi-Ethnic Study of Atherosclerosis
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    9976430
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    2019
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硝酸钾治疗射血分数保留的心力衰竭的疗效
  • 批准号:
    8963158
  • 财政年份:
    2015
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    $ 3.16万
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Exercise Therapy to Reduce Heart Failure Symptoms; Sorting Mechanisms of Benefit
运动疗法可减轻心力衰竭症状;
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