Mechanisms of the development of neuronal cell community in the central nervous system

中枢神经系统神经细胞群落的发育机制

• 批准号: 22240041
• 负责人: NAKAJIMA Kazunori
• 金额: $ 31.78万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22240041/
• 关键词: 大脳皮質; 発生・分化; 細胞移動; 神経科学; 脳・神経

We have searched for molecules that regulate the patterns of neuronal production in the subventricular zone (SVZ)/multipolar cell accumulation zone (MAZ) of the developing mouse cerebral cortex. As the results of functional assays and comparative genomic analyses, we identified some important candidates that could change the number of proliferative neuronal progenitors in the SVZ. We also have found multiple receptors and ligands that could affect the behavior of multipolar cells in the MAZ. Finally, we show that the behavior of the multipolar cells in the MAZ is controlled through the PI(3,4)P2-Lamellipodin-Ena/VASP-actin system.

我们已经搜索了调节发育中小鼠大脑皮层的室室内（SVZ）/多极细胞累积区（MAZ）中神经元产生模式的分子。作为功​​能测定和比较基因组分析的结果，我们确定了一些重要的候选者，这些候选者可以改变SVZ中增生性神经元祖细胞的数量。我们还发现了可能影响MAZ多极细胞行为的多个受体和配体。最后，我们表明MAZ中多极细胞的行为通过PI（3,4）P2-Lamellipodin-ENA/VASP-actin系统控制。

项目成果

Regulation of Cortical Neuron Migration by the Reelin Signaling Pathway

• DOI: 10.1007/s11064-011-0407-4
• 发表时间: 2011-07-01
• 期刊: NEUROCHEMICAL RESEARCH
• 影响因子: 4.4
• 作者: Honda, Takao;Kobayashi, Kazuma;Nakajima, Kazunori
• 通讯作者: Nakajima, Kazunori

Segregation and Pathfinding of Callosal Axons through EphA3 Signaling

• DOI: 10.1523/jneurosci.3303-11.2011
• 发表时间: 2011-11-09
• 期刊: JOURNAL OF NEUROSCIENCE
• 影响因子: 5.3
• 作者: Nishikimi, Mitsuaki;Oishi, Koji;Nakajima, Kazunori
• 通讯作者: Nakajima, Kazunori

神経細胞移動における受容体を介したリーリンシグナルの機能 (Functions of the Reelin signaling via its receptors in neuronal migration)

Reelin 信号通过其受体在神经元迁移中的功能

• 发表时间: 2012
• 作者: 廣田ゆき;久保健一郎;仲嶋一範
• 通讯作者: 仲嶋一範

進化の最高傑作"大脳皮質の形づくり

进化的杰作：塑造大脑皮层

• 发表时间: 2011
• 作者: Yusuke Inoue;Emiko Nakano;Itsuro Saito;Takashi Isoyama;Hidemoto Nakagawa;Toshiya Ono;Kohei Ishii;Koki Ariyoshi;Kou Imachi;Yusuke Abe;仲嶋一範
• 通讯作者: 仲嶋一範

RP58 Controls Neuronal Migration by Negative Feedback Regulation of Ngn2 Transcription in the Developing Cortex

RP58 通过负反馈调节发育中皮层 Ngn2 转录来控制神经元迁移

• 发表时间: 2012
• 作者: Chiaki Ohtaka-Maruyama;Shinobu Hirai;Akiko Miwa;Julian lk-Tsen Heng;Hiroshi Shitara;Rie Ishii;Choji Taya;Hitoshi Kawano;Masataka Kasai;Kazunori Nakajima;Haruo Okado
• 通讯作者: Haruo Okado