The mechanisms of acquiring chemo-resistance and identification of therapeutic targets in colorectal cancer stem cells.

结直肠癌干细胞获得化疗耐药性的机制和治疗靶点的鉴定。

• 批准号: 17K16571
• 负责人: IZUMI Daisuke
• 金额: $ 2.66万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16571/
• 关键词: 大腸癌幹細胞; 抗癌剤耐性; FBXW7; c-Myc; Xenograft; 癌幹細胞; LGR5; 抗癌剤; 抗がん剤耐性

项目成果

A genomewide transcriptomic approach identifies a novel gene expression signature for the detection of lymph node metastasis in patients with early stage gastric cancer

• DOI: 10.1016/j.ebiom.2019.01.057
• 发表时间: 2019-03-01
• 期刊: EBIOMEDICINE
• 影响因子: 11.1
• 作者: Izumi, Daisuke;Gao, Feng;Goel, Ajay
• 通讯作者: Goel, Ajay

Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas

• DOI: 10.1038/s41388-018-0510-y
• 发表时间: 2019-02-21
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Arima, Kota;Ohmuraya, Masaki;Ishimoto, Takatsugu
• 通讯作者: Ishimoto, Takatsugu

Impact of loss-of-function mutations at the RNF43 locus on colorectal cancer development and progression

• DOI: 10.1002/path.5098
• 发表时间: 2018-08-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Eto, Tsugio;Miyake, Keisuke;Ishimoto, Takatsugu
• 通讯作者: Ishimoto, Takatsugu