Evaluation of spacial heterogeneous distribution of ventricular repolarization and arrhythmic risk by the body surface standard electrocardiogram

体表标准心电图评价心室复极空间异质分布及心律失常风险

• 批准号: 23591032
• 负责人: IZUMI Daisuke
• 金额: $ 3.16万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591032/
• 关键词: QT延長; T波; 不整脈; 再分極; 多形性心室頻拍; 多型性心室頻拍

Fatal ventricular tachyarrhythmias often originate from enlargement of ventricular transmural dispersion of repolarization (TDR). Using canine model which showed spacial heterogeneous distribution of ventricular repolarization, we studied the relationship between the interval of the peak-to-end of the T wave (Tp-e) in ECG and the 3-dimensional repolarization heterogeneity. Tp-e in the limb leads expresses total distribution of repolarization in the left ventricle (LV). The proportion of variance of TDR in each LV region for Tp-e on V2-4 were higher in the anterior rather than in the lateral region, while those on V5-6 were higher in the lateral or midventricular/apical region rather than in the anterior or basal region. The precordial Tp-e seemed to express a certain degree of TDR at near and vertical ventricular wall. These results elucidated the electrophysiological background of the T wave and showed the alternative method of the discrimination of the fatal arrhythmic risk.

致命的心室心律失常通常源自心室透壁复极化（TDR）的扩大。使用犬模型显示心室复极化的空间异质分布，我们研究了ECG中T波（TP-E）的峰值到末端的间隔与3维复制异质性之间的关系。肢体铅中的TP-E表达左心室（LV）中复极的总分布。在V2-4上，TP-E的每个LV区域中TDR的方差比例在前部而不是横向区域，而V5-6的侧面区域则较高，而在室外或中室/顶区域中，v5-6的差异较高。前区域或基础区域。前端TP-E似乎在附近和垂直心室壁上表达一定程度的TDR。这些结果阐明了T波的电生理背景，并显示了歧视致命心律失常风险的替代方法。

项目成果

Correlation between Spatial Repolarization and Peak-to-end of the T Wave on Transmural Left Ventricular and Body Surface ECG

透壁左心室和体表心电图空间复极与T波峰-端的相关性

• 发表时间: 2011
• 作者: Daisuke Izumi;Masaomi Chinushi;Kenichi Iijima;Kanae Hasegawa;Akinori Sato;Hiroshi Furushima;Yoshifusa Aizawa
• 通讯作者: Yoshifusa Aizawa

Correlation between the T Peak-to-End Interval (Tp-e) on the Surface Precordial Leads ECG and the Intracardiac Spacial LV Repolarization Distribution

表面心前导联心电图 T 峰至端间期 (Tp-e) 与心内空间 LV 复极分布之间的相关性

• 作者: 伊藤哲也;川茂幸;Sato Akinori;Daisuke Izumi
• 通讯作者: Daisuke Izumi

Augmentation of the J wave by rapid pacing in a patient with vasospastic angina.

• DOI: 10.1016/j.ijcard.2013.12.121
• 发表时间: 2014-03
• 期刊: International journal of cardiology
• 影响因子: 3.5
• 作者: A. Sato;Hiroshi Watanabe;K. Sonoda;M. Chinushi;T. Tsuda;D. Izumi;H. Furushima;T. Minamino

Malfunction of cardiac resynchronization therapy due to subsequent fracture of the ring and tip conductors of a co-radial left ventricular bipolar lead

由于同径向左心室双极导线的环和尖端导体随后断裂而导致心脏再同步治疗故障

• 发表时间: 2013
• 期刊: Intern Med
• 作者: Sato A;Chinushi M;Izumi D;Furushima H;Minamino T.
• 通讯作者: Minamino T.

Blood pressure and autonomic responses to electrical stimulation of the renal arterial nerves before and after ablation of the renal artery

• DOI: 10.1016/j.ijcard.2014.09.168
• 发表时间: 2014-12-15
• 期刊: INTERNATIONAL JOURNAL OF CARDIOLOGY
• 影响因子: 3.5
• 作者: Hilbert, Sebastian;Kosiuk, Jedrzej;Bollmann, Andreas
• 通讯作者: Bollmann, Andreas