Impaired function of extracellular matrix 1 alters the fibrogenic and carcinogenic properties: implications of underlying mechanisms for the pathogenesis of lichen sclerosus

细胞外基质 1 功能受损会改变纤维形成和致癌特性：硬化性地衣发病机制的潜在影响

• 批准号: 17K16334
• 负责人: Utsunomiya Natsuko
• 金额: $ 2.41万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2017
• 资助国家: 日本
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17K16334/
• 关键词: 硬化性苔癬; ECM1; 自己抗体; 基底膜; 皮膚診断学; 皮膚腫瘍

项目成果

Impaired function of ECM1 underlies the pathogenic disorganization of vascular and basement membrane molecules in lichen sclerosus

ECM1 功能受损是硬化性苔藓中血管和基底膜分子致病性紊乱的基础

• 发表时间: 2019
• 作者: Lim SK;Mohamed MS;Wang H;Hartono;Hazawa M;Kobayashi A;Voon DC;Kodera N;Ando T and Wong RW;三好剛一;Natsuko Utsunomiya
• 通讯作者: Natsuko Utsunomiya

Detection of serum autoantibodies to extracellular matrix protein 1 (ECM1) and relevant abnormal expression of hemidesmosomal antigens in lichen sclerosus

硬化性苔藓血清细胞外基质蛋白1（ECM1）自身抗体及半桥粒抗原相关异常表达的检测

• 发表时间: 2018
• 作者: Yasuda Takeshi;Kagawa Wataru;Tajima Katsushi;Natsuko Utsunomiya
• 通讯作者: Natsuko Utsunomiya

Dietary supplement product composed of natural ingredients as a suspected cause of erythema multiforme: a case report and identification for the confident false-positivity of lymphocyte transformation test.

由天然成分组成的膳食补充剂产品疑似引起多形红斑：淋巴细胞转化试验可信假阳性的病例报告和鉴定。

• DOI: 10.1111/1346-8138.14739
• 发表时间: 2019
• 期刊: Journal of Dermatology
• 影响因子: 3.1
• 作者: Satoshi Ebata;Ayumi Yoshizaki;Takemichi Fukasawa;Takasgi Yamashita;Shunsuke Miura;Ryosuke Saigusa;Megumi Hirabayashi;Asako Yoshizaki;Kaname Akamata;Yoshihide Asano;Yutaka Kazoe;Kazuma Mawatari;Takehiko Kitamori;Shinichi Sato;Natsuko Utsunomiya
• 通讯作者: Natsuko Utsunomiya

Serodiagnostic utility and in vivo expression profile of hemidesmosomal antigens in lichen sclerosus: a confocal laser scanning immunofluorescence microscopic study

硬化性地衣中半桥粒抗原的血清诊断效用和体内表达谱：共聚焦激光扫描免疫荧光显微镜研究

• 发表时间: 2017
• 作者: Miyoshi T;Oku H;Asahara S;Okamoto A;Kokame K;Nakai M;Nishimura K;Otsuka F;Higashiyama A;Yoshimatsu J;Miyata T.;Natsuko Utsunomiya
• 通讯作者: Natsuko Utsunomiya

Circulating IgG autoantibodies to ECM1 contribute to the altered expression of hemidesmosomal and vascular antigens in lichen sclerosus skin

ECM1 循环 IgG 自身抗体导致硬化性苔藓皮肤中半桥粒和血管抗原表达的改变

• 发表时间: 2017
• 作者: Natsuga K;Nishie W;Nishimura M;Shinkuma S;Watanabe M;Izumi K;Nakamura H;Hirako Y;Shimizu H;Natsuko Utsunomiya
• 通讯作者: Natsuko Utsunomiya