Formulation of dispersed systems via (melt) emulsification: Process design, in situ diagnostics and regulation

通过（熔融）乳化配制分散系统：工艺设计、原位诊断和调节

• 批准号: 504809428
• 负责人: Professor Dr. Knut Graichen
• 金额: --
• 依托单位: Lehrstuhl für Regelungstechnik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/504809428?language=en
• 关键词: Formulation; dispersed; systems; via; melt

The aim of this project is the automated production of liquid-liquid disperse systems via melt emulsification, whereby in this process emulsification takes place at elevated temperature. The products obtained after cooling are dispersions of spherical nanoparticles or microparticles. Within the scope of this project, a melt emulsification device for the automated production of product particles with a well-defined particle size distribution (PSD) will be further developed. The PSD has a significant influence on the subsequent product properties, such as flow behavior or drug release kinetics. The PSD of the products is determined by the complex interaction of competing mechanisms. These are, in particular, droplet breakup in a rotor-stator device as a result of shear and elongation stress, as well as coalescence and further ripening, which in turn depend on the system composition, i.e. the emulsifier used (type, concentration) and the dispersion phase (viscosity, volume fraction). Therefore, for a better process understanding and an active process control, possibilities for in situ determination of the PSD are urgently required. In this project, a novel fiber-coupled measurement system based on broadband elastic light scattering is developed for in situ measurement of the PSD. The system will be validated on reference particle systems and applied to the emulsification process. Furthermore, a hybrid process model is developed, which is the basis for the design of a model predictive control of the process. The model predictive control in combination with the in situ measurement will provide the possibility for an active process control and the production of emulsions with predefined properties and a simultaneous optimization of the process time.

该项目的目标是通过熔融乳化自动生产液-液分散系统，在此过程中乳化在高温下发生。冷却后得到的产物为球形纳米颗粒或微米颗粒的分散体。在该项目范围内，将进一步开发一种熔体乳化装置，用于自动生产具有明确粒度分布（PSD）的产品颗粒。 PSD 对后续产品特性（例如流动行为或药物释放动力学）具有重大影响。产品的PSD是由竞争机制的复杂相互作用决定的。特别是，由于剪切和伸长应力，以及聚结和进一步熟化，转子-定子装置中的液滴破裂，这又取决于系统的组成，即所使用的乳化剂（类型、浓度）和分散相（粘度、体积分数）。因此，为了更好地理解过程和主动进行过程控制，迫切需要原位确定 PSD 的可能性。在该项目中，开发了一种基于宽带弹性光散射的新型光纤耦合测量系统，用于 PSD 的原位测量。该系统将在参考颗粒系统上进行验证并应用于乳化过程。此外，还开发了混合过程模型，这是过程模型预测控制设计的基础。模型预测控制与原位测量相结合将为主动过程控制和具有预定义特性的乳液的生产以及同时优化过程时间提供可能性。