Cell surface antigenic molecules as targets for immunotherapy

细胞表面抗原分子作为免疫治疗的靶标

• 批准号: 17016049
• 负责人: HINODA Yuji
• 金额: $ 28.8万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016049/
• 关键词: がん; 免疫療法; 細胞表面抗原分子; 樹状細胞; mRNA; Wntシグナル経路; frizzled-7; 大腸癌; Frizzled-7; si-RNA; 樹状細胞療法; 細胞プロセシング; rizzled-7; 大腸癌細胞; siRNA; 免疫学的モニタリング; 結核菌抗原; Interferon-γ; 抗体療法; RHAMM; モノクローナル抗体

For the purpose of development of the immunotherapy targeting cell surface antigenic molecules, we evaluated dendritic cell therapy using mRNA as antigen and antibody therapy in this study. For dendritic cell therapy, we performed the preclinical studies with several mouse models and then its clinical application in liver, biliary and pancreatic cancer patients. With regard to antibody therapy, we examined the molecules that express in cancer stem cells and found that a receptor molecule, Frizzled-7, is highly expressed in colorectal cancer and could be a potential therapeutic target.

为了开发靶向细胞表面抗原分子的免疫疗法，我们在这项研究中使用mRNA作为抗原和抗体疗法评估了树突状细胞疗法。对于树突状细胞疗法，我们通过几种小鼠模型进行了临床前研究，然后在肝脏，胆道和胰腺癌患者中进行了临床应用。关于抗体疗法，我们检查了在癌症干细胞中表达的分子，发现受体分子卷曲7在结直肠癌中高度表达，并且可能是潜在的治疗靶点。

项目成果

Polymorphisms of DNA repair genes are risk factors for prostate cancer

• DOI: 10.1016/j.ejca.2006.11.005
• 发表时间: 2007-01-01
• 期刊: EUROPEAN JOURNAL OF CANCER
• 影响因子: 8.4
• 作者: Hirata, Hiroshi;Hinoda, Yuji;Dahiya, Rajuir
• 通讯作者: Dahiya, Rajuir

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis

• DOI: 10.1093/carcin/bgi029
• 发表时间: 2005-05-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Nosho, K;Yoshida, M;Imai, K
• 通讯作者: Imai, K

Aneuploidy Predicts Outcome in Patients with Endometrial Carcinoma and Is Related to Lack of CDH13 Hypermethylation

• DOI: 10.1158/1078-0432.ccr-07-4609
• 发表时间: 2008-06
• 期刊: Clinical Cancer Research
• 影响因子: 11.5
• 作者: Y. Suehiro;T. Okada;Takae Okada;K. Anno;N. Okayama;Koji Ueno;Mikako Hiura;Mikiko Nakamura;T. K

polymorphisms are risk factors for endometrial cancer susceptibility

多态性是子宫内膜癌易感性的危险因素

• 发表时间: 2008
• 期刊: Cancer 112
• 作者: Hirata H;Hinoda Y;Okayama N;Suehiro Y;Kawamoto K;Kikuno N;Rabban JT;Chen LM;Dahiya R. CYP1A1;SULT1A1;SULT1E1
• 通讯作者: SULT1E1

Vaccine therapy with dendritic cells transfected with II13ra2 mRNA for glioma in mice.

使用转染 II13ra2 mRNA 的树突状细胞进行小鼠神经胶质瘤疫苗治疗。

• 发表时间: 2009
• 期刊: J Neurosurg Epub ahead of print
• 作者: Hirata H;Hinoda Y;Kikuno N;Suehiro Y;Shahryari V;Ahmad AE;Tabatabai ZL;Igawa M;Dahiya R;Okada Toshiyuki;Ueno Koji;Saka Makoto
• 通讯作者: Saka Makoto