Functional Development of Neural Circuits

神经回路的功能发育

• 批准号: 07279102
• 负责人: TSUMOTO Tadaharu
• 金额: $ 57.66万
• 依托单位: Osaka University Graduate School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-07279102/
• 关键词: Brain; Neural Circuits; Development; Neuron; Synapse; Differentiation; Growth; Plasticity; 長期増強

This project addressed a question of how neural circuits are formed and functionally developed so as to execute the higher brain function. To elucidate mechanisms underlying the formation and functional development of neural circuits in the brain, we took multidisciplinary approaches in this project. Thus, a close collaboration among researchers with different methodologies was essential for success of this project. After such a collaboration among members of this research project, we succeeded in obtaining many excellent results which were published in top-rank international journals. In this fiscal year we have edited a report of their achievements including a list of their publications. This report has been sent to researchers who are working in related fields and the members of this research project.

该项目解决了神经回路如何形成和功能发育以执行高级大脑功能的问题。为了阐明大脑神经回路形成和功能发展的机制，我们在这个项目中采取了多学科方法。因此，采用不同方法的研究人员之间的密切合作对于该项目的成功至关重要。经过该研究项目成员之间的合作，我们成功地获得了许多优秀的成果，并在国际顶级期刊上发表。在本财年，我们编辑了一份关于他们的成就的报告，包括他们的出版物清单。本报告已发送给相关领域的研究人员和本研究项目的成员。

项目成果

Shirasaki,R.,Mirzayan,C.,Tessier-Lavigne,M.,et al.: "Guidance of circumferentially growing axons by netrin-dependent and independent floor plate chemotropism in the vertebrate brain." Neuron. 17. 1079-1088 (1996)

Shirasaki,R.、Mirzayan,C.、Tessier-Lavigne,M.等人：“脊椎动物大脑中依赖于 netrin 和独立的底板趋化性对轴突周向生长的指导。”

Otsu,Y.,Kimura,F.,Tsumoto,T.: "Hebbian induction of LTP in visual cortex: A perforated patch clamp study in cultured neurons." J. Neurophysiol.74. 2437-2444 (1995)

Otsu,Y.、Kimura,F.、Tsumoto,T.：“视觉皮层中 LTP 的 Hebbian 诱导：培养神经元中的穿孔膜片钳研究。”

Kojima, N., Ishibashi, H., Obata, K. and Kandel, E.R.: "Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice"Learning & Memory. 5. 429-445 (1998)

Kojima, N.、Ishibashi, H.、Obata, K. 和 Kandel, E.R.：“fyn 转基因小鼠中 N-甲基-D-天冬氨酸受体亚基 2B 的癫痫易感性更高，酪氨酸磷酸化增强”学习

Allen, C. N., Jiang, Z., Teshima, K., Darkand, T., Ikeda, M. et al.: "Orphanin-FQ (OFQ) modulates the activity of suprachiasmatic nucleus neurons"J. Neuroscience. 19. 2152-2160 (1999)

Allen, C. N.、Jiang, Z.、Teshima, K.、Darkand, T.、Ikeda, M. 等人：“Orphanin-FQ (OFQ) 调节视交叉上核神经元的活动”J.

Kinoshita,S.,Yasuda,H.,Taniguchi,N.et al.: "Brain-derived neurotrophic factor prevents low-frequency inputs from inducing long-term depression in the developing visual cortex." J.Neuroscience. 19. 2122-2130 (1999)

Kinoshita,S.、Yasuda,H.、Taniguchi,N.等人：“脑源性神经营养因子可防止低频输入在发育中的视觉皮层中诱发长期抑郁。”