Biological Response of the Arterial Wall to Carotid Artery Stenting

动脉壁对颈动脉支架置入术的生物学反应

• 批准号: 14571308
• 负责人: MATSUSHIMA Satoshi
• 金额: $ 1.86万
• 依托单位: Mie University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571308/
• 关键词: carotid artery stenosis; stenting; restenosis; vascular endothelial cells; atheroma; atherosclerosis; endovascular treatment; 粥腫; 頚部頚動脈; 血管壁細胞; 頚部頚動脈狭窄症

Stenting of carotid arteries has emerged as an alternative to endarterectomy for the treatment of carotid artery diseases. This procedure has become safe, with a high success rate, following the introduction of protection devices prevent distal embolism, although in-stent restenosis is still a major clinical issue after stenting, and occurs in 4% to 8% of cases. Several cellular and molecular events may develop sequentially after vascular injury caused by balloon angioplasty and stenting. However, there are few reports about the biological response of the arterial wall to carotid artery stenting. In the present study, we evaluated the local pathological changes in the carotid arteries of hypercholesterolemic rabbits.In the result, we made the excellent rabbit model of atherosclerosis by endothelial injuries of the common carotid arteries using a balloon catheter following to receive chow containing 1 % cholesterol. In the atherosclerosis rabbit model, tenascin-C (Tn-C) was expressed in the inner side of the carotid arterial wall. The expression of Tn-C was inhibited by angiotensin II receptor blocker. This finding suggest that the expression of Tn-C is regulated by angiotensin and Tn-C may be involved in the atherosclerotic change of the carotid artery.

颈动脉支架的支架已成为颈动脉疾病治疗颈椎切除术的替代方法。在引入防护装置阻止远端栓塞后，该程序已变得安全，并具有很高的成功率，尽管支架后狭窄仍然是主要的临床问题，并且发生在4％至8％的病例中。在球囊血管成形术和支架上引起的血管损伤后，几个细胞和分子事件可能会依次发展。但是，关于动脉壁对颈动脉支架的生物学反应的报道很少。在本研究中，我们评估了高胆固醇血症兔的颈动脉的局部病理变化。在结果中，我们使用常见的颈动脉内皮动脉的内皮动脉损伤制造了极好的兔动脉粥样硬化模型，并使用气球导管随后接受了含有1％胆固醇的气球。在动脉粥样硬化的兔模型中，Tenascin-C（TN-C）在颈动脉壁的内侧表达。血管紧张素II受体阻滞剂抑制TN-C的表达。这一发现表明，TN-C的表达受血管紧张素和TN-C调节，可能与颈动脉的动脉粥样硬化变化有关。

项目成果

Naoki Toma: "Histopathological findings in a human carotid arteny after stent implantation"J.Neurosurg.. 98. 199-204 (2003)

Naoki Toma：“支架植入后人颈动脉的组织病理学发现”J.Neurosurg.. 98. 199-204 (2003)

Naoki Toma: "Histological findings in a human carotid artery after stent implantation"J of Neurosurgery. 98(1). 199-204 (2003)

Naoki Toma：“支架植入后人颈动脉的组织学发现”神经外科杂志。

Naoki Toma: "Histopathological firdings in a human carotid artery after stent implantation"J.Neurosurg.. 98. 199-204 (2003)

Naoki Toma：“支架植入后人颈动脉的组织病理学现象”J.Neurosurg.. 98. 199-204 (2003)