Antioxidant Agents Therapy for Esophageal Mucosa with Inducible Nitric Oxide Syntlaase Expression

抗氧化剂治疗具有诱导型一氧化氮合酶表达的食管粘膜

• 批准号: 14571230
• 负责人: TANAKA Hikaru
• 金额: $ 1.6万
• 依托单位: Tokai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14571230/
• 关键词: esophageal carcinoma; rat; iNOS; anthocyanins; curemin; sesamin

2002 : We made the antioxidation feed which mixed blueberry (anthocyanins)10% sesame (sesamin) 10%, turmeric (curumin)10% with each. It was given the group of treatments rat N-Methyl-N-anyhtitrosamine (following AMN) since administered antioxidation feed for one week. The crowd whom administered antioxidation feed and AMN to and the control crowd whom administered normal feed and ANN to administered it with 12 weeks for ten weeks for each eight weeks, and sacrifice was made to die. The appearance of iNOS was accepted in eight weeks, but cancer-Causing frequency was held down. For ten weeks, carcinogenesis was accepted in 12 weeks by all rats. As the intake situation of antioxidation feed, some feed with turmeric bit it and remained in a bottom of a gauge in large quantities, and it was thought that there were not most of the effects of turmeric, but when continued administering a cancer-causing agent together, a carcinogenesis prevention effect by quality of these antioxides might dela … More y carcinogenesis temporarily, but that the effect that completely controlled carcinogenesis was not provided was supposed.2003 : We analyzed a study result of 2002 again. If we did carcinogenesis entirely in eight weeks and bred it by the dosage for eight weeks in conventional AMN afterwards until 12 weeks, careinogenesis of 100% was the provided situation and, with a rat of control, was different from the time that the cancer-causing time by AMN thought about at first greatly. Because AMN which we used conventionally purchased AMN from an other chemical reagent company because release was called off, it is thought that the cancer-causing time changed by a difference of purity of AMN. A rat carcinogenesis experiment by AMN was cancer-causing experiment system developed in this institution and there was not a document and added enough examination besides conventional accumulation data about the dosage density and a dosage period of AMN. Now do cancer-causing fundamental experiment between the dosage period of AMN for six weeks for five weeks for four weeks for two weeks.1 set the result between the dosage period for the cause again and am to administer AMN to a special feed dosage rat. Less

2002年：我们制作了蓝莓（花青素）10％、芝麻（芝麻素）10％、姜黄（姜黄素）10％各混合的抗氧化饲料，给予治疗组大鼠N-甲基-N-anyhtitrosamine（以下AMN）。给予抗氧化饲料和AMN的人群以及给予正常饲料和AMN的对照人群。每8周10周进行12周的ANN，在8周内处死iNOS的出现，但致癌频率在10周内被确认为致癌。根据所有大鼠的抗氧化饲料的摄入情况，一些含有姜黄的饲料被咬碎并大量残留在计量器的底部，并且认为姜黄的大部分效果没有，但是当继续施用时。与致癌剂一起使用时，这些抗氧化剂的质量可能会暂时抑制致癌作用，但并没有提供完全控制致癌作用的效果。2003年：我们再次分析了2002年的研究结果。我们在八周内完全进行了致癌作用，然后在常规AMN中按八周的剂量进行饲养，直到12周为止，所提供的情况是100％的致癌作用，并且用一只大鼠以往使用的AMN因为发售被中止而从其他化学试剂公司购买了AMN，所以与最初考虑的AMN的致癌时间大大不同。 AMN的大鼠致癌实验是本机构开发的致癌实验系统，除了AMN的剂量和密度剂量周期的常规积累数据外，没有文献并添加了足够的检查。现在做6周、5周、4周、2周的AMN给药期间的致癌性基本实验。1再次设定病因的给药期间的结果，将AMN给予特殊饲料剂量的大鼠。