Fundamentals of plasma disinfection for the inactivation of viruses in aerosol particles: Influence of liquid films

等离子消毒灭活气溶胶颗粒中病毒的基本原理：液膜的影响

• 批准号: 468784496
• 负责人: Professorin Dr. Nina Merkert
• 金额: --
• 依托单位: Institut für Technische Mechanik
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2021
• 资助国家: 德国
• 起止时间: 2020-12-31 至 2021-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/468784496?language=en
• 关键词: Fundamentals; plasma; disinfection; inactivation; viruses

Cold atmospheric plasmas such as Dielectric Barrier Discharge (DBD) plasmas are used to inactivate microorganisms and to eliminate toxic or undesirable pollutants in air or exhaust streams and are even employed to selectively target the destruction of cancer cells. The Covid-19 pandemic raised the demand for inactivation of viruses in aerosol particles. One idea is to filter the particles and then use cold plasma to eliminate the viruses. The other approach is to inactivate the viruses directly in the aerosol state. However, in the case of liquid aerosol particles, the viruses are surrounded by moisture layers and the interaction between the plasma species and the liquid layer is still poorly understood.Atomistic simulations can provide fundamental insights into plasma disinfection processes that are difficult to access, especially in the aerosol state, through experiments. In this project, molecular dynamics simulations will be performed to investigate the interaction mechanisms of reactive plasma species with liquid films surrounding viruses. The plasma membrane of the virus will be modeled as a lipid bilayer. The concentration of the active species at the plasma source and their decay over time will be directly determined from experiments using UV-vis spectroscopy of the DBD plasma and a radical sensitive tracer reaction.

冷大气等离子体，例如介质阻挡放电 (DBD) 等离子体，用于灭活微生物并消除空气或废气流中的有毒或不良污染物，甚至用于选择性地破坏癌细胞。 Covid-19 大流行提高了对气溶胶颗粒中病毒灭活的需求。一种想法是过滤颗粒，然后使用冷等离子体消除病毒。另一种方法是直接以气溶胶状态灭活病毒。然而，在液体气溶胶颗粒的情况下，病毒被水分层包围，并且等离子体物质和液体层之间的相互作用仍然知之甚少。原子模拟可以为难以实现的等离子体消毒过程提供基本见解，特别是在气溶胶状态下，通过实验。在该项目中，将进行分子动力学模拟来研究活性等离子体物质与病毒周围液膜的相互作用机制。 病毒的质膜将被建模为脂质双层。等离子体源处活性物质的浓度及其随时间的衰减将通过使用 DBD 等离子体的紫外可见光谱和自由基敏感示踪反应的实验直接确定。