Immunological background in paraneoplastic neurological syndrome and its therapeutic approach

副肿瘤性神经综合征的免疫背景及其治疗方法

• 批准号: 17590868
• 负责人: TANAKA Keiko
• 金额: $ 2.24万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590868/
• 关键词: paraneoplastic neurological syndrome; immunological background; lymphocyte subpopulation; regulatory T cell; quantitative RT-PCR

Paraneoplastic neurological syndrome (PNS) is categorized in autoimmune neurological disease ; in that, cancer immunity and autoimmune mechanisms to neuronal tissue are both elicited in PNS. Because the tumor is often very small to be detected with conventional screening system, anti-tumor immunity might be accelerated at least in early stage of PNS. Furthermore, PNS develops in a small population of patients who have similar tumor pathology, suggesting that PNS patients might have special immunological backgrounds to tune up immunity on tumor and nervous tissue.To inspect this hypothesis, we analyzed prevalence of lymphocyte subpopulation and regulatory T cell (Treg) mRNA expression of functional molecules such as FOXP3, TGF-pi, CTLA-4 and GITR in Treg-rich fraction from peripheral blood of PNS patients.As the results, the expression of FOXP3 and CTLA-4 mRNA were diminished in PNS, group compared to cancer patients without neurological symptom, suggesting PNS develops in those cancer patients having dysfunction in Treg system. These results have brought a new insight in understanding the pathomechanisms of PNS and in constructing a treatment strategy for underlying cancer.

副肿瘤神经综合征（PNS）属于自身免疫性神经系统疾病；其中，癌症免疫和神经元组织的自身免疫机制都是在三七总皂甙中引发的。由于肿瘤通常很小，常规筛查系统无法检测到，因此至少在PNS的早期阶段，抗肿瘤免疫可能会加速。此外，PNS 发生在一小部分具有相似肿瘤病理学的患者中，这表明 PNS 患者可能具有特殊的免疫背景来调节肿瘤和神经组织的免疫力。为了检验这一假设，我们分析了淋巴细胞亚群和调节性 T 细胞的患病率PNS 患者外周血富含 Treg 组分中 FOXP3、TGF-pi、CTLA-4 和 GITR 等功能分子 (Treg) mRNA 表达情况。与无神经系统症状的癌症患者相比，PNS 组中 CTLA-4 mRNA 减少，表明 Treg 系统功能障碍的癌症患者中发生了 PNS。这些结果为理解 PNS 的病理机制和构建潜在癌症的治疗策略带来了新的见解。

项目成果

整形外科学大系 22巻 越智隆弘編(製本中)

《骨科》第 22 卷，大智贵宏主编（已装订）

• 作者: Arakawa T;Niikurat T;Tajima H;Kita Y;Maruyama M;Arimura K and Hashiguchi T;田中惠子
• 通讯作者: 田中惠子

Paraneoplastic cerebellar degeneration in olfactory neuroepithelioma

嗅神经上皮瘤的副肿瘤性小脑变性

• 发表时间: 2006
• 期刊: J Neurol Neurosurg Psychiatry 77
• 作者: Maeda K;et al.
• 通讯作者: et al.

A case of HIV encephalopathy showing Lower body parkinsonism during HAART.

一例 HIV 脑病在 HAART 期间显示下半身帕金森病。

• 发表时间: 2006
• 期刊: Brain Nerve 58(6)
• 作者: Shimohata T;Takado Y;Terashima K;Tsukada H;Gejyo F;Tanaka K;Nishizawa M.
• 通讯作者: Nishizawa M.

Reevaluation of the usefulness of creatinine % in urine

重新评估%20of%20%20有用性%20of%20肌酐%20%%20in%20尿液

• 发表时间: 2006
• 期刊: Brain Nerve 58(1)
• 作者: Shimohata T;Umeda M;Tanaka K;Nishizawa M.
• 通讯作者: Nishizawa M.

イヌ回虫性脊髄炎の1例

犬蛔虫性脊髓炎一例

• 发表时间: 2007
• 期刊: 日本内科学会誌 96(1)
• 作者: Hanajima R;Dostrovsky JO;Lozano AM;Chen R;Matsui M;石原智彦ら
• 通讯作者: 石原智彦ら