Investigation of the unknown factor over stimulating the VEGF prodution in Crow-Fukase syndrome.

Crow-Fukase 综合征中过度刺激 VEGF 产生的未知因素的调查。

• 批准号: 15590901
• 负责人: HASHIGUCHI Teruto
• 金额: $ 2.24万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590901/
• 关键词: Crow-Fukase syndrome; POEMS syndrome; vascular endothelial growth factor; VEGF; platelet; megakaryocyte; embryonic lethality; B cell; platelet; Crow-Fukase syndrome; POEMS syndrome; transgenic mouse; megakaryocyte; atherosclerosis; diabetic

Vascular endothelial growth factor(VEGF) is an endothelial cell-specific potent mitogen that induces angiogenesis and microvascular hyperpermeability. Megakaryocytes and platelets are a very rich source of circulating VEGF. Platelet VEGF is bioactive as a direct angiogenic growth factor, and may play a very important role in wound healing and atherosclerosis (J Thromb Haemost.2003,(12):2589-93). In Crow-Fukase(POEMS) syndrome, platelet VEGF markedly elevated. We reported a case diagnosed as Crow-Fukase syndrome, in which the serial platelet count and VEGF concentration were determined before and during the state of disseminated intravascular coagulation(DIC). The serum VEGF concentration was noted to be gradually decreased prior to DIC, after which it abruptly decreased with a corresponding drop in platelet count upon the onset of DIC. The physiological effects of VEGF are viewed as one of the causative factors in DIC and its abrupt and excessive release may have caused the exacerbation of the patient's clinical symptoms(Tokashiki T et al. Intern Med. 2003,42(12):1240-3). The factors which stimulate the over-production of platelet VEGF in Crow-Fukase syndrome is still unknown. To investigate this unknown factor, we are planning to facilitate the proteomics technology in the next project.

血管内皮生长因子（VEGF）是一种内皮细胞特异性有效促有促有丝分裂原，可诱导血管生成和微血管高过度性。巨核细胞和血小板是循环中的非常丰富的来源。血小板VEGF作为直接血管生长因子是生物活性的，并且在伤口愈合和动脉粥样硬化中可能起着非常重要的作用（J Thromb Haimost.2003，（12）：2589-93）。在乌鸦般的（诗）综合征中，血小板VEGF明显升高。我们报道了一个被诊断为乌鸦症综合征的病例，其中串行血小板计数和VEGF浓度是在散布的血管内凝血状态之前和期间确定的。血清VEGF浓度被认为在DIC之前逐渐降低，此后，随着DIC发作的相应下降，它突然降低了。 VEGF的生理影响被视为DIC中的原因之一，其突然和过度释放可能导致患者的临床症状加剧（Tokashiki T等人Intern Med 2003,42（12）：1240-3）。刺激血小板VEGF过度生产的因素仍然未知。为了调查这个未知因素，我们计划在下一个项目中促进蛋白质组学技术。

项目成果

血管の発生と新生 -基礎と臨床- 血小板性VEGF増多症としてのCrow-Fukase症候群(p60-67)

血管的发育和新生 - 基础和临床 - 血小板 VEGF 增加导致的 Crow-Fukase 综合征 (p60-67)

• 发表时间: 2003
• 作者: 橋口照人;梅原藤雄;有村公良;丸山征郎
• 通讯作者: 丸山征郎

Takayo Arisato: "Highly accumulated platelet vascular endothelial growth factor in coagulant thrombotic region."J Thromb Haemost. 1・12. 2589-2593 (2003)

Takayo Arisato：“凝血性血栓区域中高度积累的血小板血管内皮生长因子。”J Thromb Haemost 1・12 2589-2593（2003）。

Takashi Tokashiki: "Predictive value of serial platelet count and VEGF determination for the management of DIC in the Crow-Fukase(POEMS) syndrome"Intern Med. 42・12. 1240-1243 (2003)

Takashi Tokashiki：“连续血小板计数和 VEGF 测定对 Crow-Fukase（POEMS）综合征 DIC 治疗的预测价值” Intern Med 42・12（2003）。

The agonist of the protease-activated receptor-1(PAR) but not PAR3 mimics thrombin-induced vascular endothelial growth factor release in human smooth muscle cells.

蛋白酶激活受体 1 (PAR) 而非 PAR3 的激动剂可模拟凝血酶诱导的人类平滑肌细胞中血管内皮生长因子的释放。

• 发表时间: 2003
• 期刊: Cell Mol Life Sci. 60(8)
• 作者: Arisato T;Sarker KP;Kawahara K;Nakata M;Hashiguchi T;Osame M;Kitajima I;Maruyama I.
• 通讯作者: Maruyama I.

血管の発生と新生-基礎と臨床- 血小板性VEGF増多症としてのCrow-Fukase症候群

血管的发育和新生 - 基础和临床 - 血小板 VEGF 增加导致的 Crow-Fukase 综合征

• 发表时间: 2003
• 作者: 橋口照人;梅原藤雄;有村公良;丸山征郎
• 通讯作者: 丸山征郎