Mechanisms of penile erection during REM sleep regulated by the hypothalamo-limbic system.

快速眼动睡眠期间阴茎勃起的机制受下丘脑边缘系统调节。

• 批准号: 15590211
• 负责人: KOYAMA Yoshimasa
• 金额: $ 2.3万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590211/
• 关键词: Preoptic area; laterodorsal tegmental nucleus; limbic system; paraventricular nucleus; REM sleep; acetylcholine; penile erection; rat; 分界条床核

To elucidate the mechanisms involved in regulation of penile erection during REM sleep, we electrically stimulated the proptic/hypothalamic areas, in and around the brainstem cholinergic neurons (larerodorsal tegmental nucleus, LDT) and recorded the neuronal activity in the LDT.Spontaneous normal penile erection pattern is composed of slow increase of pressure in corpus spongeneosum of the penis (CSP) and sharp increase in CSP pressure synchronized with burstic bulbospongiosus (BS) muscle activity. In unanesthetized, head-restrained rats, penile erection which was almost similar to the normal spontaneous one was evoked after the electrical stimulation to the medial preoptic area (MPOA), lateral preoptic area (LPOA), paraventricular nucleus (PVN) or bed nucleus of stria terminalis (BST). Among them, latency of the response was shorter in the PVN. In urethane anesthetized rats, erection was evoked only from the MPOA and PVN. Erection was evoked also in and around the LDT. In some areas, the evoked erection pattern was almost normal, while in other areas only the slow increase in CSP pressure or sharp increase of CSP pressure and BS muscle activity was observed. Some of the the cholinergic neurons in the LDT showed phasic firing before the sharp CSP increase, while others showed tonic increase for several seconds before the initiation of erection.These results indicate that lateral part and medial part of the preoptic area are involved in penile erection in different way. PVN is the final out put in the hypothalamus for penile erection. The LDT contains systems which selectively activate the component of penile erection and those which inhibit penile erection.

为了阐明快速眼动睡眠期间阴茎勃起调节的机制，我们电刺激了脑干胆碱能神经元（左背侧被盖核，LDT）内部和周围的前突/下丘脑区域，并记录了 LDT 中的神经元活动。 自发的正常阴茎勃起该模式由阴茎海绵体 (CSP) 压力缓慢增加和与突发性同步的 CSP 压力急剧增加组成。球海绵体肌 (BS) 肌肉活动。在未麻醉、头部受限的大鼠中，电刺激内侧视前区（MPOA）、外侧视前区（LPOA）、室旁核（PVN）或床核后，诱发几乎与正常自发勃起相似的阴茎勃起。终纹（BST）。其中，PVN 的响应潜伏期较短。在乌拉坦麻醉的大鼠中，仅由 MPOA 和 PVN 诱发勃起。 LDT 内及其周围也引起勃起。在某些区域，诱发勃起模式几乎正常，而在其他区域，仅观察到 CSP 压力缓慢增加或 CSP 压力和 BS 肌肉活动急剧增加。 LDT中的一些胆碱能神经元在CSP急剧增加之前表现出阶段性放电，而另一些则在勃起开始前表现出持续数秒的强直性增加。这些结果表明视前区的外侧部分和内侧部分参与了阴茎勃起以不同的方式。 PVN 是下丘脑中阴茎勃起的最后输出。 LDT 包含选择性激活阴茎勃起成分和抑制阴茎勃起成分的系统。

项目成果

The cholinergic neurons in the brainstem are involved in fluctuation of blood pressure during paradoxical sleep

脑干中的胆碱能神经元参与反常睡眠期间的血压波动

• 发表时间: 2003
• 期刊: Sleep and Biological Rhythms 1
• 作者: Iwasaki H.;Koyama Y.;Tanaka Y.Kawauchi A.;Jodo E.;Kayama Y.;Miki T.;Koyama Y. et al.;Koyama Y. et al.
• 通讯作者: Koyama Y. et al.

State-dependent effects of orexin on the serotonergic dorsal raphe neurons in the rat

食欲素对大鼠中缝背侧血清素神经元的状态依赖性影响

• 发表时间: 2005
• 期刊: Regul Pept 126
• 作者: Takahashi K

Modulation of desmopressin of neuronal activity in brainstem micturition center

去氨加压素对脑干排尿中枢神经元活动的调节

• 发表时间: 2004
• 期刊: Urology 63
• 作者: Iwasaki H.;Koyama Y.et al.
• 通讯作者: Koyama Y.et al.

Nitric oxide, induced by kainite application, regulates norepinephrine release in the laterodorsal tegmental nucleus of rats

应用红藻土诱导的一氧化氮调节大鼠背侧被盖核中去甲肾上腺素的释放

• 发表时间: 2003
• 期刊: Sleep and Biological Rhythms 1
• 作者: Kodama T.;Honda Y.;Koyama Y
• 通讯作者: Koyama Y

Is state-dependent alternation of slow dynamics in central single neurons during sleep present in the rat ventroposterior thalamic nucleus?

大鼠丘脑腹后核中是否存在睡眠期间中央单个神经元缓慢动态的状态依赖性交替？

• 发表时间: 2004
• 期刊: Neuroscience Research 48
• 作者: J.Zhou;T.Hagiwara;T.Hagiwara;M.Yamamoto et al.
• 通讯作者: M.Yamamoto et al.