The role of autoimmune response and pathogenesis of neurological diseases in animals

动物自身免疫反应的作用和神经系统疾病的发病机制

• 批准号: 15580289
• 负责人: UCHIDA Kazuyuki
• 金额: $ 2.3万
• 依托单位: University of Miyazaki
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15580289/
• 关键词: Canine; Necrotizing meningoencephalitis; Granulomatous meningoencephalitis; Sensory neuropathy; Poly radiculoneuritis; Autoantibody; Auto-immune disease; T lymphocyte; 脳神経症; 神経節根炎; 自己免疫; ネコ; ボルナ病; 神経疾患; 免疫介在性疾患; 神経節・根炎; 肉芽腫性髄膜脳; T細胞; 壊死性

During the period of Grant-in-Aid for Scientific Research for 4 years, several new evidences concerning inflammatory neuronal disorders in dogs have been obtained. Our previous research has been revealed the presence of the autoantibody against astrocytes in canine necrotizing meningoencephalitis (NME) and granulomatous meningoencephalitis (GME). The significance of the antibodies in these canine diseases has been confirmed by corroborative research with other laboratory (J. Vet. Med. Sci. 66: 295-297, 2004). In the inflammatory process of canine NME and GME, the expression of MHC class II by microglia and/or macrophages and infiltration of T lymphocytes were considered to be the important events. Moreover, in the brain with NME, there was prominent deposit of IgG and C3 within astrocytes and their processes, suggesting the antibody dependent cellular injury (J. Vet. Med. Sci. 65: 1233-1239, 2003). All these findings indicate that canine NME and GME are autoantibody-associated inflamma … More tory diseases. Antibody and complement-associated cellular injury in canine NME and T-cell mediated dilated type allergy response in GME might be important for the pathogenesis of these diseases, respectively.Besides, the pathogenesis of canine ganglioradiculoneuritis (sensory neuropathy) has been also investigated. The results indicated the importance of T cell mediated immune reaction and the prescription by common dose of corticosteroid seemed to be difficult to obtain complete emission. By indirect immunofluorescence assay using sera from affected dogs, no autoantibodies against canine nerve tissues were detected. The results might indicate that T cell-mediated immune response is most likely to play the major role in the pathogenesis of canine sensory neuropathy is suggested in idiopathic canine polyradiculitis (Coon hunt paralysis). Publication process for these results is in progress.Several neurological diseases other than inflammatory disorders in dogs and cats have been collected and some of them were reported in scientific journals by the supp ort of this grant. Less

在为期四年的科学研究资助期间，我们获得了一些关于犬炎症性神经元疾病的新证据，揭示了犬坏死性脑膜脑炎（NME）和犬星形胶质细胞的自身抗体的存在。肉芽肿性脑膜脑炎 (GME) 的抗体在这些犬类疾病中的重要性已通过其他实验室的实证研究得到证实 (J. Vet. Med. (Sci. 66: 295-297, 2004)。此外，在犬NME和GME的炎症过程中，小胶质细胞和/或巨噬细胞的MHC II类表达和T淋巴细胞的浸润被认为是重要的事件。患有 NME 的大脑中，星形胶质细胞及其突起内有 IgG 和 C3 的显着沉积，表明抗体依赖性细胞损伤（J. Vet. Med. Sci. 65： 1233-1239, 2003)。所有这些发现表明犬 NME 和 GME 是自身抗体相关的炎症……更多犬 NME 中抗体和补体相关的细胞损伤以及 GME 中 T 细胞介导的扩张型过敏反应可能很重要。此外，还对犬神经节神经根神经炎（感觉神经病）的发病机制进行了研究。表明T细胞介导的免疫反应的重要性，并且普通剂量的皮质类固醇处方似乎难以获得完全发射。通过使用受影响狗的血清进行间接免疫荧光测定，没有检测到针对犬神经组织的自身抗体。在特发性犬多发性神经根炎（库恩狩猎麻痹）中，T 细胞介导的免疫反应很可能在犬感觉神经病的发病机制中发挥主要作用。在这项资助的支持下，我们收集了除狗和猫炎症性疾病之外的几种神经系统疾病，其中一些在科学期刊上进行了报道。

项目成果

脳内にクリプトコッカスとボルナ病ウイルスが重複感染した猫の1例

猫脑部同时感染隐球菌和博尔纳病病毒一例

• 发表时间: 2006
• 期刊: 動物臨床医学 15・2
• 作者: 田村慎司;田村由美子;鈴木宣考;大岡 恵;長谷川考寿;内田和幸;渡邊洋平;朝長啓三
• 通讯作者: 朝長啓三

Multiple metastases of thyroid cancer in the cranium and pituitary gland in two dogs

两只狗的甲状腺癌颅骨和垂体多发转移

• 发表时间: 2007
• 期刊: Journal of Small Animal Practice 48
• 作者: S.Tamura;Y.Tamura;N.Suzuoka;K.Uchida.(他2名5番目)
• 通讯作者: K.Uchida.(他2名5番目)

Two cases of feline malignant craniopharyngioma

猫恶性颅咽管瘤二例

• 发表时间: 2005
• 期刊: Vet.Pathol. 42(5)
• 作者: T.Nagata;H.Nakayama;K.Uchida;他8名
• 通讯作者: 他8名

M.Suzuki, K.Uchida, et al.: "A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs"J. Vet. Med. Sci.. 65/11. 1319-1324 (2003)

M.Suzuki，K.Uchida，等：“狗肉芽肿性脑膜脑脊髓炎和中央恶性组织细胞增多症的比较病理学研究”J。

A comparative pathological study on granulomatous meningoencephalomyelitis and central malignant histiocytosis in dogs.

• DOI: 10.1292/jvms.65.1319
• 发表时间: 2003-12
• 期刊: The Journal of veterinary medical science
• 作者: M. Suzuki;K. Uchida;M. Morozumi;T. Yanai;H. Nakayama;R. Yamaguchi;S. Tateyama