An Etiologic and therapeutic study on canine necrotizing meningoencephalitis

犬坏死性脑膜脑炎的病因及治疗研究

• 批准号: 20380169
• 负责人: MATSUKI Naoaki
• 金额: $ 7.99万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380169/
• 关键词: 臨床病理; 病態; 犬; 壊死性髄膜脳炎; パグ脳炎; 自己抗体; 治療選択; GFAP; βアクチン; 遺伝性疾患; 治療

Genetic, etiologic and therapeutic studies were performed on canine mecrotizing meningoencephalitis (NME). The genetic study consisted of the determination of glial fibrillary acidic protein in the cerebrospinal fluids from Pug dogs in 4 families. As a result, NME was suggested to be an autosomal recessive disorder. By the etiologic studies, GFAP-antibody complexes and anti-transglutaminase autoantibodies were demonstrated in the NME cerebrospinal fluids. In the therapeutic study, three immunosuppressive protocols were examined on dogs with NME. No significant difference was observed in the survival times and neurological scores among the therapeutic protocols.

对犬坏死性脑膜脑炎（NME）进行了遗传学、病因学和治疗研究。遗传学研究包括测定 4 个家族的哈巴狗脑脊液中的神经胶质原纤维酸性蛋白。因此，NME 被认为是一种常染色体隐性遗传疾病。通过病因学研究，NME脑脊液中发现了GFAP抗体复合物和抗转谷氨酰胺酶自身抗体。在治疗研究中，对患有 NME 的狗检查了三种免疫抑制方案。治疗方案之间的生存时间和神经学评分没有观察到显着差异。

项目成果

Seial examinations of anti-GFAP autoantibodies in cerebrospinal fluids in canine necrotizing meninggoencephalitis.

犬坏死性脑膜脑炎脑脊液中抗 GFAP 自身抗体的连续检查。

• 发表时间: 2009
• 期刊: J. Vet. Med. Sci. 71
• 作者: Matsuki;N.;Takahashi;S.;Yaegashi;M.;Tamahara;S.;and Ono;k.
• 通讯作者: k.

犬の壊死性髄膜脳炎における新たな自己抗原の同定

犬坏死性脑膜脑炎中一种新自身抗原的鉴定

• 发表时间: 2009
• 作者: 八重樫昌也、松木直章;ら
• 通讯作者: ら