Functional roles of cortico-basal gangila loops in conditional motor learning

皮质基底神经节环在条件运动学习中的功能作用

• 批准号: 15500290
• 负责人: INASE Masahiko
• 金额: $ 2.11万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500290/
• 关键词: conditional motor kearning; cerebral cortex; prefrontal cortex; primate; neuronal activity; basal ganglia; stimulus response; association learning; 運動学習; 神経生理学; conditional motor kearning; cerebral cortex; prefrontal cortex; primate; neuronal activity; basal ganglia; stimulus response; association learning; 運動学習; 神経生理学

In order to examine functional roles of the prefrontal cortex in arbitrary visuomotor association, we recorded neuronal activity in the medial prefrontal cortex, area 9m, of a behaving monkey during conditional visuomotor learning. The monkey was presented a cueing visual stimulus, and following a delay period required to push, pull, or turn a manipulator according to the cue. Under the control condition three cues instructed the monkey to the three responses in a block of trials. After a few months of training the animal was familiar with these associations. Under the learning condition, two of the three familiar cues and one novel cue were presented in a block. The monkey needed to learn a new cue-response association by trial and error. Area 9m neurons responded to cue presentation. The Cue responses changed whether a cue was familiar or novel. A group of area 9m neurons responded to a novel cue, bur not to familiar ones. Other group of neurons responded to familiar cues, but not to a novel one. In a subgroup of these familiar cue-selective neurons the cue responses were enhanced under the learning condition compared to the control condition. These results suggest that cue familiarity is represented in area 9m activity and/or that the activity may be involved in action selection during the arbitrary visuomotor association learning.

为了检查任意视觉运动关联中前额叶皮层的功能作用，我们记录了在条件视觉运动过程中表现猴子的内侧前额叶皮层中的神经元活性。向猴子展示了一个提示视觉刺激，然后根据提示推动，拉或转动操纵器所需的延迟期。在控制条件下，三个提示指示猴子在试验中的三个响应。经过几个月的训练，动物熟悉这些关联。在学习条件下，三个熟悉的提示和一个新颖的提示中有两个在一个区块中呈现。猴子需要通过反复试验来学习新的提示响应关联。区域9M神经元对提示介绍做出了反应。提示反应改变了提示是熟悉还是新颖。一群9M神经元的区域对一个新颖的提示做出了反应，对熟悉的提示不熟悉。其他一组神经元对熟悉的提示做出了反应，但对新颖的提示没有反应。在这些熟悉的提示选择性神经元的子组中，与对照条件相比，在学习条件下，提示反应得到了增强。这些结果表明，在9M活动中表示提示熟悉度和/或在任意视觉运动结合学习期间的活动可能参与了行动选择。