Functional organization of the prefrontal cortex

前额皮质的功能组织

• 批准号: 12680787
• 负责人: INASE Masahiko
• 金额: $ 1.73万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12680787/
• 关键词: Frontal lobe; Cingulate cortex; Basal ganglia; Input; Output; Anterograde tracing; 大脳基底核; 前頭連合野; 機能単位; 逆行性標識法

The prefrontal association cortex is the highest brain center related to perception, memory intelligence, planning, and so on. The cortex is further divided into many areas. We have been examining input-output arrangement of these areas to elucidate functional organization of the frontal cortex.In the present project we investigated the organization of cingulate motor areas inputs to the primate basal ganglia. The cingulate motor areas reside within regions lining the cingulate sulcus and are divided into rostral and caudal parts. Recent studies suggest that the rostral and caudal cingulate motor areas participate in distinct aspects of motor function : The former plays a role in higher-order cognitive control of movements, whereas the latter is more directly involved in their execution. Identified forelimb representations of the rostral and caudal cingulate motor areas were injected with different anterograde tracers, and the distribution patterns of labeled 'terminals were analyzed i … More n the striatum and the subthalamic nucleus. Corticostriatal inputs from the rostral and caudal cingulate motor areas were located within the rostral striatum, with the highest density in the striatal cell bridges or the ventrolateral portions of the putamen, respectively. There was no substantial overlap between these input zones. Similarly, a certain segregation of input zones from the rostral and caudal cingulate motor areas occurred along the mediolateral axis of the subthalamic nucleus. It has also been revealed that corticostriatal and corticosubthalamic input zones from the rostral cingulate motor area considerably overlapped those from the presupplementary motor area, while the input zones from the caudal cingulate motor area displayed a large overlap with those from the primary motor cortex. The present results indicate that a parallel design essentially underlies motor information processing in the cortico-basal ganglia loop derived from the rostral and caudal cingulate motor areas. Less

前额叶关联是与感知，记忆智力，计划等的最高大脑中心目前，我们调查了灵长类动物基底神经节的运动区域。顺行示踪剂，标记的末端的分布模式被分析了纹状体和三核核。这些输入区域之间没有实质性的重叠。与主要电动机皮层的大重叠相结合。

项目成果

M.Inase: "Pallidal activity is involved in visuomotor association learning in monkeys"Eur.J.Neurosci. 14. 897-901 (2001)

M.Inase：“苍白球活动参与猴子的视觉运动关联学习”Eur.J.Neurosci。

稲瀬正彦: "脳による運動と行動の制御"理学療法ジャーナル. 35. 206-208 (2001)

Masahiko Inase：“大脑对运动和行为的控制”物理治疗杂志 35. 206-208 (2001)。

稲瀬正彦: "条件付運動学習における大脳基底核の役割"脳の科学. 23. 1041-1047 (2001)

Masahiko Inase：“基底神经节在条件运动学习中的作用”《脑科学》23. 1041-1047 (2001)。

稲瀬正彦: "視床下核をめぐる神経回路網"医学のあゆみ. 196. 714-717 (2001)

Masahiko Inase：“丘脑底核周围的神经网络”医学史 196. 714-717 (2001)。

Inase M: "Functional roles of the basal ganglia in conditional motor learning."Brain Science. 11. 13-21 (2001)

Inase M：“基底神经节在条件运动学习中的功能作用。”脑科学。