Studies on the cortical processing of visuomotor transformation

视觉运动转换的皮层处理研究

基本信息

批准号：
14580765
负责人：
TERAO Yasuo
金额：
$ 2.18万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14580765/
关键词：
TMS virtual lesion visuomotor transformation hemispheric predominance motor cortex reaction time human dorsolateral prefrontal cortex 頭頂葉前頭葉

项目摘要

Motor activities in daily life are usually guided by vision and thus involve a process whereby visual information is* transformed into plans of motor actions. To investigate, the cortical processing required for visuomotor transformation, we applied focal transcranial magnetic stimulation (TMS) over various cortical regions while the subjects performed in a visuomotor task. This was to induce a transient derangement in cortical processing ("virtual lesion") and behavioral changes.The task was to press either of the two buttons (either left of right) with the left or right hand quickly in response to two visual cues presented successively at random intervals on a monitor screen. The first cue (precue) provided the subjects with full, partial or no advance information about the mot action to be performed, while the second cue fully specified the action and also served as the go-signal for the response. TMS was applied over 15 locations over the left and right hemisphere at various interv … More als (100, 150, 200, 250, 300, 350 ms) after the second cue and before the reaction time (RT) [over the dorsolateral prefrontal cortex (DLPFC), premotor cortex, motor cortex, anterior parietal cortex (apc), and posterior parietal cortex (ppc) of both hemispheres]. In control trials, TMS was delivered at locations -5, -2, 5, 0, 2.5, 5 cm anterior to Cz on the midline at the same intervals. RT was measured from the time of go-signal, and the delay induced by TMS was calculated by subtracting the control RT from test RTs with TMS delivered over lateral scalp regions.In control trials, RT became shorter with the amount of advance information. TMS induced a delay in RT bilaterally over posterior cortical sites (APC, PPC) when applied at early intervals (100-150ms), over anterior cortical sites (DLPFC) at intermediate intervals (200-250ms), and over the left motor cortex at late intervals (300-350ms) regardless of the amount of precued information. In addition, at an intermediate interval (150-200ms), TMS induced a delay over DLPFC in partial or no information precue conditions, and the delay decreased with the increase in precued information. The results suggest a progression of cortical information flow from posterior to anterior cortical regions, and finally to the motor cortex, with a left hemispheric dominance. Less

日常生活中的运动活动通常以视觉为指导，因此涉及一个过程，即视觉信息被*转化为运动动作计划。为了调查视觉运动转化所需的皮质处理，我们在各个皮质区域应用了局灶性经颅磁刺激（TMS），而受试者在视觉运动任务中进行。这是为了诱导皮层处理（“虚拟病变”）和行为变化的短暂演化。任务是按两个按钮（右左）中的任何一个，左手或右手快速响应于在监视器屏幕上以随机间隔成功显示的两个视觉提示。第一个提示（Precue）为受试者提供了有关要执行的MOT操作的完整，部分或没有预先的信息，而第二个提示则完全指定了该动作，并且还充当了响应的信号。 TMS was applied over 15 locations over the left and right hemisphere at various intervals … More als (100, 150, 200, 250, 300, 350 ms) after the second cue and before the reaction time (RT) [over the dorsolate prefrontal cortex (DLPFC), premotor cortex, motor cortex, anterior parietal cortex (apc), and posterior parietal cortex两个半球的（PPC）。在对照试验中，TMS以相同的间隔在中线上的位置-5、5、5、5、0、2.5、5厘米前的Cz前交付。从Go-Signal的时间开始测量RT，TMS引起的延迟是通过从横向头皮区域传递的TMS中减去对照RT来计算的。在控制试验中，RT随着预先信息的数量而变短。当在早期间隔（100-150ms）应用后皮质位点（APC，PPC）上，TMS诱导了双侧的RT延迟（APC，PPC），以中间间隔（200-250mms）在前皮质部位（DLPFC）上延迟（200-250mms），并在左手左手Cortex（200-250ms）上以晚期间隔（300-350ms）（300-350ms）（300-350ms）的范围内无效。另外，在中间间隔（150-200ms）中，TMS在部分或没有信息预处理条件下诱导DLPFC的延迟，并且随着预示信息的增加而延迟减少。结果表明，皮质信息流从后部到抗抗原的区域，最后是运动皮层，并具有左半球优势。较少的