Investigation on neurologic abnormality induced by 1-bromoproane and individual variation in susceptibility

1-溴丙烷所致神经异常及个体易感性差异的研究

基本信息

批准号：
14406015
负责人：
ICHIHARA Gaku
金额：
$ 9.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

1)Analysis on the cases intoxicated with 1-bromopropane in North Carolina in United States of America.The worker (A)working in a cushion factory in United States used an adhesive containing mainly 1-bromopropane as solvent. Decrease in vibration sense, anesthesia such as burning sensation, numbness in buttocks, frontal thighs, lower things and foot, and stumbling were found in the worker. The symptoms suggesting disorder in the central nervous system such as irritation, depression and headache were also observed. Colleagues (B)and (C)of this worker showed also similar symptoms to the above. As the workers (A)and (B)left the workplace at the investigation, we evaluated an individual exposure level for the worker (C)with passive samplers. The exposure level was 60 to 261,averaged 133 ppm.2)Investigation on neurologic disorders in the workers in 1-bromopropane factories in Jiangsu Province in China.The comparison of twenty-three workers exposed to 1-bromopropane after matching with age and sex showed elongation in distal latency in lower limbs as well as lower scores in neurobehavioral testing. Fifteen workers among the exposed showed decrease in vibration sense clearly.3)Evaluation of individual exposure levels, metabolites and nerve conduction velocities. The individual variations were assessed with them. Urinary metabolites, N-acetyl-S-propylcysteine were investigated in workers exposed to 1-bromopropane. The examined indices such as nerve conduction velocity did not show any clear dose-response relationship among workers. It suggested (1)passive samplers and urinary metabolites did show only short-term exposure that is not associated with long-term exposure to 1-bromopropane and (2)possible difference in individual variations in susceptibilities. Further investigation is required to address this issue.

1）对美国北卡罗来纳州北卡罗来纳州1-溴丙烷陶醉的病例的分析。在美国的一家靠垫工厂工作的工人（a）使用了主要含有1-溴丙烷的粘合剂作为溶剂。在振动意义上减少，麻醉，例如燃烧的感觉，臀部麻木，额叶，较低的脚和脚以及绊脚石，以及在工人中发现了绊脚石。还观察到中枢神经系统中的症状，例如刺激，抑郁和头痛。该工人的同事（b）和（c）也显示出与上述类似的症状。当工人（a）和（b）在调查中离开工作场所时，我们评估了用被动抽样器的工人（c）个人接触水平。暴露水平为60至261，平均为133 ppm。显示下肢远端潜伏期的伸长率以及神经行为测试的较低分数。裸露的15名工人在振动意义上明显下降。3）评估个体暴露水平，代谢产物和神经传导速度。对他们进行了评估。在暴露于1-溴丙烷的工人中研究了泌尿代谢物，N-乙酰基丙基半胱氨酸。诸如神经传导速度之类的检查指标没有显示工人之间任何明显的剂量反应关系。它提出（1）被动抽样器和尿代谢物的确显示出短期暴露，这与长期暴露于1-溴丙烷和（2）敏感性变化可能差异。需要进一步调查来解决此问题。