Study on the self-setting cell regulation membrane aimed for the tissue regeneration

以组织再生为目的的自凝固细胞调节膜的研究

• 批准号: 13470415
• 负责人: ISHIKAWA Kunio
• 金额: $ 9.79万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470415/
• 关键词: Cell barrier membrane; alginate; regenerative medicine; self-setting; GTR; GBR; apatite cement; apatite form; 細胞制御膜; 塩化カルシウム; 吸収性; アルギン酸ナトリウム; 骨芽細胞; 吸収性多孔体; 骨再生; 骨再建

Objective of this investigation was to study method regarding to the regeneration of bone defect using self-setting barrier membrane. In this year, use of apatite cement or apatite form was evaluated to keep the form of self-setting barrier membrane in relatively larger bone defect area. We found that use of apatite cement or apatite form was very effective to regulate the form of regenerative bone. Although we found osteoconductivity on the surface of apatite cement, the amount of regenerated bone was limited.. On the other hand, we found enough new bone formation when we used apatite form to keep the shape of self-setting barrier membrane. However, we sometimes found that apatite form break the self-setting barrier membrane. We concluded therefore that some substrate with high porosity is useful to keep the shape of self-setting barrier membrane arid resulting regenerated bone. We have to select operation procedure so that the supporting substrate would not break the self-setting barrier membrane. We also have to investigate so that self-setting barrier membrane with higher mechanical strength can be fabricated.

这项研究的目的是研究有关使用自定义屏障膜再生骨缺损的方法。在今年，评估了使用磷灰石水泥或磷灰石形式的使用，以将自设定的屏障膜的形式保持在相对较大的骨缺损区域。我们发现，使用磷灰石水泥或磷灰石形式非常有效地调节再生骨的形式。尽管我们发现磷灰石水泥表面上的骨电导率，但再生骨的量受到限制。另一方面，当我们使用磷灰石形式以保持自我设定的屏障膜的形状时，我们发现了足够的新骨形成。但是，有时我们会发现磷灰石形式破坏了自我设定的屏障膜。因此，我们得出的结论是，一些具有高孔隙率的底物可用于保持自构建的屏障膜干旱的形状，导致骨骼的再生骨。我们必须选择操作过程，以便支撑底物不会破坏自定义的屏障膜。我们还必须研究，以便可以制造具有更高机械强度的自我设定的屏障膜。

项目成果

Ishikawa K: "Basic properties of apatite cement containing spherical tetracalcium phosphate made with plasma melting method."J Mater Sci : Mater Med. 15. 13-17 (2004)

Ishikawa K：“等离子熔融法制备的含有球形磷酸四钙的磷灰石水泥的基本性能。”J Mater Sci : Mater Med。

Momota Y: "Evaluation of feasibility of hydroxyapatite putty as a local hemostatic agent for bone."J Biomed Mater Res. 63. 542-547 (2003)

Momota Y：“羟基磷灰石腻子作为骨局部止血剂的可行性评估。”J Biomed Mater Res。

Ishikawa K: "Basic properties of apatite cement containing spherical tetracalcium phosphate made with plasma melting method."J Mater Sci : Mater Med. 15(1). 13-17 (2004)

Ishikawa K：“等离子熔融法制备的含有球形磷酸四钙的磷灰石水泥的基本性能。”J Mater Sci : Mater Med。

Momota Y: "Evaluation of feasibility of hydroxyapatite putty as a local hempstatic agent for bone."J Biomed Mater Res : Appl Biomater. 63(5). 542-547 (2002)

Momota Y：“评估羟基磷灰石油灰作为骨局部麻药的可行性。”J Biomed Mater Res：Appl Biomater。