THE MECHANISM OF THE EXPRESSION OF TOLERANCE FOR ISCHEMIA BY ISCHEMIC PRECONDITIONING IN FETAL BRAIN.

胎脑缺血预处理表达缺血耐受的机制。

• 批准号: 12470349
• 负责人: ARAKI Tsutomu
• 金额: $ 8.19万
• 依托单位: NIPPON MEDICAL SCHOOL
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470349/
• 关键词: brain ischemia; brain hypoxia; fetus; ischemic preconditioning; adenosine; theophylline; ischemic tolerance; 5'-nucleotidase; Brain; Adenosine; 5'-nucleotidase

[PURPOSE] The purpose of this study is to examine the relationship between ischemic preconditioning and ischemic tolerance in fetal brain, and evaluated the mechanism of the expression of the tolerance for ischemia by ischemic preconditioning.[METHOD] We performed ischemic preconditioning by repeated umbilical cord occlusion, and then inducted fetal brain ischemia and hypoxia by repeated umbilical cord occlusion in ten chronically instrumented fetal sheep with and without adenosine agonists and antagonists.[RESULTS] Fetal brain tolerance for ischemia was enhanced by ischemic preconditioning, which was partially augmented by adenosine agonists and diminished by adenosine antagonists.[CONCLUSION] Ischemic preconditioning elicits fetal brain tolerance for ischemia, which was at least in part regulated by adenosine.

[目的]这项研究的目的是检查胎儿大脑中缺血性预处理和缺血性耐受性之间的关系，并通过缺血性预处理评估缺血性缺血的耐受性表达的机制。带有和没有腺苷激动剂和拮抗剂的仪器胎羊。[结果]缺血性预处理增强了胎儿脑耐缺血的耐缺血性，腺苷激动剂会部分增强，并被腺苷拮抗剂减少。

项目成果

Takeuchi. et al: "Regulation of platelet aggregation in vitro by plasma adenosine in preeclampsia"Gynecol Obstet Invest. 51・1. 36-9 (2001)

Takeuchi 等人：“先兆子痫中血浆腺苷的体外血小板聚集调节”Gynecol Obstet Invest. 51·1 (2001)。

Yoneyama Y. et al: "Changes in plasma adenosine concentration during normal pregnancy"Gynecol Obstet Invest. 50・3. 145-8 (2000)

Yoneyama Y.等人：“正常妊娠期间血浆腺苷浓度的变化”Gynecol Obstet Invest. 50・3（2000）。

Yoneyama Y, et al: "Plasma adenosine levels and the expression of P-selectin on platelets in preeclampsia"Obstet Gynecol. 印刷中. (2001)

Yoneyama Y 等人：“先兆子痫中血小板上的血浆腺苷水平和 P-选择素的表达”Obstet Gynecol 出版（2001 年）。

Suzuki S. et al.: "Incidence of intrauterine complications in monoamniotic twin gestation"Acta Gynecol Obstet. 265・2. 57-9 (2001)

Suzuki S.等：“单羊膜双胞胎妊娠中的宫内并发症的发生率”Acta Gynecol Obstet. 265・2 (2001)。

Suzuki S. et al.: "Relation between serum uric acid and plasma adenosine lelvels in women with preedampsid"Gynecol Obstet Invest. 51・3. 169-72 (2001)

Suzuki S. 等人：“患有 preedampsid 的女性血清尿酸和血浆腺苷水平之间的关系”Gynecol Obstet Invest. 169-72 (2001)。