Study on genetic and environmental factors of the etiology of incurable and serious neurological diseases in West New Guinea

西新几内亚疑难及严重神经系统疾病病因的遗传和环境因素研究

基本信息

批准号：
11691212
负责人：
SEGUCHI Harumichi
金额：
$ 3.84万
依托单位：
KOCHI MEDICAL SCHOOL
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The amyotorophic lateral sclerosis (ALS) and Parkinsonism-dementia (PD), specific incurable and serious neurological diseases, are known to be found together in unusually high incidence in Guam and New Guinea Island. Gajdusek surveyed in the southern coastal plain of West New Guinea of Indonesia form 1963 to 1985, and reported that the incidence of these diseases were extraordinarily high among the Auyu and Asmat peoples of the Edera and Obaa Kecamatans (administrative districts) near Merauke. Since then, repeated surveillances have been planned in these areas, however, they could not be performed because of the political problems and the underdeveloped atmosphere in these areas. We recognized the fact that these incurable and serious neurological diseases, ALS and PD, were still encountered many cases, when we surveyed from 1999 to 2000 in Bade and Kepi village and their suburb in the southern low marsh tropical forest plain of Irian Jaya Province of Indonesia, West New Guinea. Throug … More h the resident medical examination we found that the only one new case of ALS had appeared, but the prevalence of traumatic myelopathy and Parkinsonism had recorded extraordinarily high. However, we could not differentiate at that time whether these cases of Parkinsonism were combined with the dementia.We were able to clarify to some extent the environment of the medical condition, physical and psychological figures, and the cultural characteristics of the daily life sounding the resident of this area through the surveillance of the relationship between the aged condition and the genetic and environmental factors for this two years in the Irian Jaya Province of West New Guinea of Indonesia based at Wemena located in the central highland of this area. In the future we will try to clarify the etiology of ALS and PD, in the viewpoint of environmental factors related with the water examination, and further to clarify the real state of the cysticercosis encountered in high incidence in this area, by means of repeated surveillance by the Neurologist cooperated with the residential medical staffs. Less

在西新几内亚南部沿海平原的关岛和新几内亚岛，肌萎缩侧索硬化症（ALS）和帕金森痴呆症（PD）这两种特殊且无法治愈的严重神经系统疾病的发病率异常高。 1963 年至 1985 年间，印度尼西亚的一项研究报告称，这些疾病在埃德拉和埃德拉和阿斯马特的奥尤人和阿斯马特人中发病率极高。从那时起，马老奇附近的Obaa Kecamatans（行政区）就计划在这些地区进行多次监视，但由于这些地区的政治问题和不发达的气氛，我们认识到这些地区的情况无法治愈和严重。 1999年至2000年，我们在伊里安查亚省南部低沼泽热带森林平原的Bade和Kepi村及其郊区进行调查时，神经系统疾病ALS和PD仍然存在很多病例。印度尼西亚、西新几内亚。通过住院体检，我们发现出现了唯一一例新的ALS病例，但创伤性脊髓病和帕金森病的患病率却异常高，但当时我们无法区分是否存在。这些帕金森病病例与痴呆症合并存在。通过关系监测，我们能够在一定程度上明确该地区居民的医疗状况环境、身心状况、日常生活文化特征。介于老化状态之间以及这两年印度尼西亚西新几内亚伊里安查亚省位于该地区中部高地Wemena的遗传和环境因素。未来我们将尝试阐明ALS和PD的病因，今后通过神经科医师配合驻院医务人员的反复监测，结合水质检查相关的环境因素，进一步明确该地区囊虫病高发区的真实情况。