Dynamics of stress-homeosurveillance and its relevance to disease control

应激同源监测的动态及其与疾病控制的相关性

基本信息

批准号：
22249025
负责人：
TANAKA Yoshiya
金额：
$ 30.2万
依托单位：
University of Occupational and Environmental Health, Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2010
资助国家：
日本
起止时间：
2010-04-01 至 2014-03-31
项目状态：
已结题

项目摘要

Vital homeosurveillance is performed by receiving input signals through stress-sensors and by sending output signals to metabolic and immune systems. This study has been undertaken to clarify the dynamism in homeosurveillance by elucidating (1) the input signaling mechanisms of stress-sensing such as pain, mechanic and oxidative stress to vital brain centers including hypothalamus and (2) the output signaling mechanisms from brain centers to immune, inflammatory and bone metabolic systems in physiologic condition and disease models. The output signals via PTH/PTHrP and synthetic neurons commit to differentiation of stem cells or naïve cells to particular direction, which is involved in disease processes. Furthermore, results using disease models in which the dynamism in homeosuriveillance was regulated would bring novel strategies of disease control.

通过接收输入信号传感器并将输出信号发送到代谢和免疫的研究中，通过阐明（1）表演的输入信号机制，机械压力和氧化应激的输入信号机制（至关重要的大脑）通过（1） 2）在生理状态和疾病模型中，通过PTH/PTHRP和合成神经元在生理状态和疾病模型中的输出信号传导机制使干细胞或幼稚细胞的特定方向降低了特定的方向。裁定的居家义务中的YNANISM将带来疾病的策略。

项目成果

期刊论文数量（222）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Temporal profile of arginine vasopressin release from the neurohypophysis in response to hypertonic saline and hypotension measured using a fluorescent fusion protein

DOI：
10.1016/j.jneumeth.2011.08.004
发表时间：
2011-09-30
期刊：
JOURNAL OF NEUROSCIENCE METHODS
影响因子：
3
作者：
Yao, Song T.;Antunes, Vagner R.;Murphy, David
通讯作者：
Murphy, David

Angiotensin II type 1 receptor signaling regulates feeding behavior through anorexigenic corticotropin-releasing hormone in hypothalamus

血管紧张素 II 1 型受体信号通过下丘脑中抑制食欲的促肾上腺皮质激素释放激素调节进食行为

DOI：
10.1074/jbc.m110.192260
发表时间：
2011
期刊：
Journal of Biological Chemistry
影响因子：
4.8
作者：
Yamamoto;R. Akazawa;H. Fujihara;H. Ozasa;Y. Yasuda;N. Ito;K. Kudo;Y. Qin;Y. Ueta;Y. & Komuro;I
通讯作者：
I

Deficiency of vitamin A delays bone healing process in association with reduced BMP2 expression after drill-hole injury in mice.

DOI：
10.1016/j.bone.2010.08.016
发表时间：
2010-12
期刊：
Bone
影响因子：
4.1
作者：
Kazuhiro Tanaka;Shinya Tanaka;A. Sakai;T. Ninomiya;Y. Arai;Toshitaka Nakamura
通讯作者：
Kazuhiro Tanaka;Shinya Tanaka;A. Sakai;T. Ninomiya;Y. Arai;Toshitaka Nakamura

A calcineurin inhibitor, tacrolimus overcomes treatment-unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis.

他克莫司是一种钙调神经磷酸酶抑制剂，可克服难治性类风湿关节炎淋巴细胞上 P-糖蛋白介导的治疗无反应。