Stress-surveillance and signal network originated from dendrite of various cells

源自各种细胞树突的压力监视和信号网络

• 批准号: 18209026
• 负责人: TANAKA Yoshiya
• 金额: $ 31.45万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18209026/
• 关键词: ストレス科学; デンドライト; 樹状細胞; 神経ペプチド; ランゲルハンス細胞; 免疫系; アポトーシス; 酸化ストレス; ホメオサーベイランス

"Dendrite" is expressed on various cells including neuron in CNS and periphery, dendritic cells in immune system, Langerhans cells in skin, osteocyte in bone and so on. The dendrite receives multiple stresses and functions as stress-surveillance sensors. The cells possessing the dendrite receive stress-stimulation, transform it to multiple intracellular signals through nucleic transcription and transduce the signals to various defensive cellular functions in central nerve, immune, skin, metabolic systems in human body. Thus, we postulate that the dendrite plays a pivotal role in the self-defense system through initiating multiple stress-stimulation as a central sensor.

“树突状”在各种细胞上表达，包括中枢神经系统中的神经元和外周，免疫系统中的树突状细胞，皮肤中的兰格汉细胞，骨骼中的骨细胞等。树突接收到多种应力和功能，作为应力表现传感器。具有树突的细胞会受到应力刺激，将其通过核转录转化为多个细胞内信号，并将信号转换为中央神经，免疫，皮肤，皮肤，代谢系统的各种防御性细胞功能。因此，我们假设树突在自卫系统中起着关键作用，通过启动多重应力刺激作为中心传感器。

项目成果

Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: an interim report on RRR (remission induction by remicade in RA) study.

类风湿关节炎患者疾病活动度较低后停用英夫利昔单抗：RRR（类风湿性关节炎缓解诱导）研究的中期报告。

• 发表时间: 2009
• 作者: Y. Tanaka;T. Takeuchi;T. Mimori;N. Miyasaka;T. Koike.
• 通讯作者: T. Koike.

The oral Jak inhibitor CP-690, 550 in combination with methotrexate is efficacious, safe and well tolerated in Japanese patients with active rheumatoid arthritis with an inadequaet response to MTX alone.

口服 Jak 抑制剂 CP-690、550 与甲氨蝶呤联合治疗对单独使用 MTX 反应不足的活动性类风湿关节炎日本患者有效、安全且耐受性良好。

• 发表时间: 2009
• 作者: Y. Tanaka;M. Suzuki;H. Nakamura;S. Toyoizumi;S.H. Zwillich.
• 通讯作者: S.H. Zwillich.

Inhibitory effects of epinastine on chemokine production and MHC class II/CD54 expression in keratinocytes.

Epinastine 对角质形成细胞中趋化因子产生和 MHC II 类/CD54 表达的抑制作用。

• 发表时间: 2007
• 期刊: Journal of Dermatological Science 45.2
• 作者: Marui T;Funatogawa I;Koishi S;Yamamoto K;Matsumoto H;Hashimoto O;Nanba E;Nishida H;Sugiyama T;Kasai K;Watanabe K;Kano Y;Kato N;Sasaki T;Kobayashi M.
• 通讯作者: Kobayashi M.

Arsenic trioxide augments chk2/p53-mediated apoptosis by inhibiting oncogene wip1 phosphatase.

三氧化二砷通过抑制癌基因 wip1 磷酸酶来增强 chk2/p53 介导的细胞凋亡。

• 发表时间: 2008
• 期刊: J Biol Chem 283
• 作者: Yoda A;Toyoshima K;Onishi N;Hazaka Y;Tsukuda Y;Tsukada J;Kondo T;Tanaka Y;Minami Y.
• 通讯作者: Minami Y.

The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somato/dendritic peptide release.

apelin 对下丘脑大细胞加压素和催产素神经元电活动以及体细胞/树突肽释放的影响。

• 发表时间: 2008
• 期刊: Endocrinology 149(12)
• 作者: Tobin;A. V.;Bull;P. M.;Aruna chalam;S.;O'Carroll;A. -M.;Ueta;Y.;Ludwig;M.
• 通讯作者: M.