The effects of prenatal exposures to environmental chemicals and genetic susceptibility on growth, neurodevelopment and allergy of next generation

产前环境化学物质暴露和遗传易感性对下一代生长、神经发育和过敏的影响

• 批准号: 22249021
• 负责人: KISHI REIKO
• 金额: $ 26.87万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22249021/
• 关键词: 母子保健; 環境化学物質; 次世代影響; リスク評価; 神経行動発達; 環境遺伝交互作用; 出生体格; 出生コホート; 神経発達; PCBダイオキシン類; 代謝遺伝子多型

514 pregnant women were recruited in one obstetric hospital in Sapporo. We investigated the correlation of prenatal exposures to PCBs/PCDDs/PCDFs, PFOS and PFOA with child growth, neurodevelopment, and allergy in next generation until school age. A follow-up questionnaire was used at 18, 42, and 84 months of age to obtain relevant information including infant symptoms and lifestyle factors. The Bayley Scale of Infant Development second edition at age of 6 and 18 months, and the Kaufman Assessment Battery for Children and the Child Behavior Checklist at age 42 to 43, 84 months were employed to collect information on child behavior. At age of 84 months the Wechsler Intelligence Scale for Children was used to assess the effects of environmental chemicals on cognitive ability. The levels of PCBs/PCDDs/PCDFs and PFOS/PFOA in maternal blood were analyzed by a high-resolution gas chromatography/high-resolution mass spectrometer and liquid chromatography-tandem mass spectrometry respectively.

札幌一家产科医院招募了 514 名孕妇。我们调查了产前接触 PCBs/PCDDs/PCDFs、PFOS 和 PFOA 与儿童生长、神经发育和下一代直到学龄期过敏的相关性。在 18、42 和 84 月龄时进行随访问卷，以获得包括婴儿症状和生活方式因素在内的相关信息。采用贝利婴儿发育量表第二版（6 个月和 18 个月）、考夫曼儿童评估套组和儿童行为检查表（42 至 43 岁、84 个月）收集儿童行为信息。在 84 个月大时，使用韦克斯勒儿童智力量表来评估环境化学物质对认知能力的影响。分别采用高分辨气相色谱/高分辨质谱仪和液相色谱-串联质谱仪分析母血中PCBs/PCDDs/PCDFs和PFOS/PFOA的含量。

项目成果

Teaching to Read and Spell English Words to Japanese Middle School Students with Developmental Dyslexia

教患有发展性阅读障碍的日本中学生阅读和拼写英语单词

• 发表时间: 2011
• 作者: Okumura;Y.;Kasai;T.;& Murohashi;H;奥村安寿子・河西哲子・室橋春光;奥村安寿子・河西哲子・室橋春光;奥村安寿子・室橋春光;奥村安寿子・河西哲子・室橋春光;奥村安寿子・河西哲子・室橋春光;奥村安寿子・河西哲子・竹谷隆司・室橋春光;小川浩太・三浦徹;奥村安寿子・河西哲子・室橋春光;小川浩太・三浦徹;奥村安寿子・室橋春光
• 通讯作者: 奥村安寿子・室橋春光

Prenatal Exposure to Dioxins in Relation to Allergy and Infection in Infancy -Hokkaido Study on Environment and Children's Health-

产前接触二恶英与婴儿期过敏和感染有关 -北海道环境与儿童健康研究 -

• 发表时间: 2010
• 作者: Miyashita C;Sasaki S;Yoshioka E;Yila TA;Baba T;Braimoh TS;Kashino I;Okada E;Kobayashi S;Otake Y;Limpar M;Kajiwara J;Todaka T;Kishi R
• 通讯作者: Kishi R

Self-Reported Exposure to Environmental Tobacco Smoke and Plasma Cotinine during Pregnancy-The Hokkaido Study on Environment and Children's Health (6)

怀孕期间自述暴露于环境烟草烟雾和血浆可替宁——北海道环境与儿童健康研究（6）

• 发表时间: 2010
• 作者: Braimoh TS;Sasaki S;Yila TA;Baba T;Miyashita C;Okada E;Kashino I;Kobayashi S;Yoshioka E;Kishi R
• 通讯作者: Kishi R

‐発達障害と認知:読み書きの困難‐、「発達の基盤:身体、認知、情動」

-发育障碍和认知：阅读和写作困难-，“发展的基础：身体、认知、情感”

• 发表时间: 2012
• 作者: 室橋春光(著);日本発達心理学会(編);根ヶ山光一・仲真紀子(責任編集)
• 通讯作者: 根ヶ山光一・仲真紀子(責任編集)

生後42ヶ月児における認知能と胎児期PCB・ダイオキシン類曝露との関連-環境と子どもの北海道スタディ(4)

42个月大婴儿认知能力与胎儿接触PCBs和二恶英的关系——北海道环境与儿童研究(4)

• 发表时间: 2011
• 作者: Soma K;Fu YJ;Wakabayashi K;OnoderaO;Kakita A;Takahashi H;小西香苗,坂晋,佐々木成子,鷲野考揚,吉岡英治,梶原淳睦,戸高尊,中島そのみ,岸玲子
• 通讯作者: 小西香苗,坂晋,佐々木成子,鷲野考揚,吉岡英治,梶原淳睦,戸高尊,中島そのみ,岸玲子