Prevention of liver metastasis after resection of colorecatal cancer using immunoconjugates composed of anticancer drug and chimeric antibody

抗癌药物与嵌合抗体免疫偶联物预防结直肠癌切除术后肝转移

• 批准号: 11470260
• 负责人: YAMAGUCHI Toshiharu
• 金额: $ 8.83万
• 依托单位: Japanese Foundation for Cancer Research (2000-2002)Kyoto Prefectural University of Medicine (1999)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470260/
• 关键词: Chimeric Antibody; Photosensitve Substances; Metastasis; Photodynamic Therapy; Gastric Cancer; Immunoconjugate; Targeting Therapy; Experimental Model; 移転モデル; 光線力学治療; レーザー; 蛍光

Stability of the immunoconjugate had been examined both in the room temperature and freezer. Drug activity and antibody activity were perfectly reserved at least 12 months in the freezer. The safety of the chimeric antibody part of the immunoconjugate chA7-NCS could not be confirmed yet. The phase I clinical study to evaluate the maximum tolerant dose of the immunoconjugate , human immune reaction, and biodistribution of the conjugate could not be finished. Next step of this project should be the phase I clinical study of immunoconjugate.

免疫缀合物的稳定性已在室温和冰箱下进行了检查。药物活性和抗体活性在冰箱中可完美保存至少12个月。免疫缀合物 chA7-NCS 的嵌合抗体部分的安全性尚未得到证实。评估免疫结合物最大耐受剂量、人体免疫反应和结合物生物分布的I期临床研究尚未完成。该项目的下一步应该是免疫偶联物的I期临床研究。

项目成果

Yamaguchi.T., Nakajima , T. ,Ohyama,S, ,Ohta,K. ,M atsubara ,T. ,Ueno , M. ,Ya mamoto J. , Muto ,T.: "How to prevent recurrence of scirrhous gastric cancer"Surgical Therapy. 86. 1081-1086 (2002)

山口T.、中岛T.、大山S、太田K.

山口俊晴: "「スキルス」胃癌の再発予防に何をすべきか"外科治療. 86. 1081-1086 (2002)

Toshiharu Yamaguchi：“如何预防硬质胃癌复发”《外科治疗》86. 1081-1086 (2002)。

山口俊晴: "抗腫瘍薬療法の周辺drug delivery system"臨床医. 28. 1746-1747 (2002)

Toshiharu Yamaguchi：“围绕抗肿瘤药物治疗的药物输送系统”临床医生。28. 1746-1747 (2002)

山口俊晴: "胃癌治療のガイドラインをめぐって-癌治療の新しい潮流-"日本医師会雑誌. 127. 67-72 (2002)

Toshiharu Yamaguchi：“胃癌治疗指南 - 癌症治疗的新趋势”日本医学会杂志 127. 67-72 (2002)。

山口俊晴: "胃癌のSentinel Node Navigation Surgery"外科. 63. 819-822 (2001)

Toshiharu Yamaguchi：“胃癌前哨淋巴结导航手术”Surg。 63. 819-822 (2001)