Application of MPC (basic study) for development of antibacterial denture surface

MPC（基础研究）在抗菌义齿表面开发中的应用

• 批准号: 24890238
• 负责人: TAKAHASHI Nana
• 金额: $ 1.91万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-08-31 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-24890238/
• 关键词: MPC; 義歯; デンチャープラーク; 歯学; MPC polymer; denture base resin; anti-biofilm formation; surface modification

MPC polymers have significant biocompatibility, are highly resistant to cell adhesion, and do not react with multiproteins. We have been studying for development of "the anti-adhesive denture" unattached dental plaque by MPC coating to denture surface. Previously, we have tested MPC coating on the dentures by using graft polymerization method, which have superior durability. However, we have found operability problem on this method. So, we examined the new method such as coating of contents mixed 2-HEMA and MPC, and of PMBPAz polymer copolymerized MPC and BMA. At the moment, we have reached clinical study with the PMBMAz polymer coating.

MPC聚合物具有显着的生物相容性，对细胞粘附具有高度抗性，并且不与多蛋白反应。我们一直在研究通过MPC涂层到义齿表面开发“抗粘附性义齿”未附着的牙齿。以前，我们已经使用具有较高耐用性的移植聚合方法在义齿上测试了MPC涂层。但是，我们在此方法上发现了可操作性问题。因此，我们检查了新方法，例如含量混合2-HEMA和MPC，以及PMBPAZ聚合物共聚的MPC和BMA的涂层。目前，我们已经使用PMBMAZ聚合物涂料进行了临床研究。

项目成果

EVALUATION OF THE DURABILITY AND ANTIADHESIVE ACTION OF 2-METHACRYLOYLOXYETHYL PHOSPHORYLCHOLINE GRAFTING ON AN ACRYLIC RESIN DENTURE BASE MATERIAL

• DOI: 10.1016/j.prosdent.2013.08.020
• 发表时间: 2014-08-01
• 期刊: JOURNAL OF PROSTHETIC DENTISTRY
• 影响因子: 4.6
• 作者: Takahashi, Nana;Lwasa, Fuminori;Baba, Kazuyoshi
• 通讯作者: Baba, Kazuyoshi