The association between ADH7 polymorphisms and alcohol consumption

ADH7 多态性与饮酒的关系

• 批准号: 22890250
• 负责人: OZE Isao
• 金额: $ 2.01万
• 依托单位: Aichi Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22890250/
• 关键词: 疫学; ゲノム

ADH1B and ADH1C gene polymorphisms, rs1229984 and rs1693482 are associated with alcohol drinking habit and esophageal cancer risk, through modulating catalytic activity of ADH enzymes. However, there were few evidences about the association between other five ADHs and alcohol drinking. We investigated ADH gene polymorphisms and alcohol drinking habit of 4062 subjects. Rs1154460, the loci on ADH7 had significant association with alcohol drinking.

ADH1B 和 ADH1C 基因多态性 rs1229984 和 rs1693482 通过调节 ADH 酶的催化活性与饮酒习惯和食道癌风险相关。然而，很少有证据表明其他五种 ADH 与饮酒之间存在关联。我们调查了 4062 名受试者的 ADH 基因多态性和饮酒习惯。 Rs1154460，ADH7 上的位点与饮酒显着相关。

项目成果

Comparison between self-reported facial flushing after alcohol consumption and ALDH2 Glu504Lys polymorphism for risk of upper aerodigestive tract cancer in a Japanese population

• DOI: 10.1111/j.1349-7006.2010.01599.x
• 发表时间: 2010-08-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Oze, Isao;Matsuo, Keitaro;Tanaka, Hideo
• 通讯作者: Tanaka, Hideo

飲酒行動に及ぼすアルコール脱水素酵素遺伝子多型の影響

乙醇脱氢酶基因多态性对饮酒行为的影响

• 发表时间: 2012
• 作者: Paquet M. et al.;including Iizuka T.;尾瀬功
• 通讯作者: 尾瀬功

ALDH2遺伝子多型と酒類別消費量の関連:J-MICC横断研究

ALDH2 基因多态性与饮酒之间的关联：J-MICC 横断面研究

• 发表时间: 2011
• 作者: Moynier F.;Dai W.;Yokoyama T.;Hu Y.;Paquet M.;Abe Y.;Aleon J.;Alexander C.M.O'D;Amari S.;Amelin Y. ... Yabuta H. ... et al.;尾瀬功
• 通讯作者: 尾瀬功