Elucidation of the bone formation mechanism through Akt-mTOR

通过 Akt-mTOR 阐明骨形成机制

• 批准号: 21890194
• 负责人: ROKUTANDA Satoshi
• 金额: $ 1.66万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-21890194/
• 关键词: 骨格形成機構; Akt-mTOR; Runx2; Stat1,3; S6K; 4EBP1; Akt; mTOR; Stat13; TAK; Stat pathway

I clarified a function of Akt for the bone formation until now. Akt regulates a large number of signal molecules in the down stream. I decided to perform function elucidation for the frame formation mechanism of those signal molecules.

到目前为止，我阐明了Akt对于骨形成的功能。 Akt 调节下游大量信号分子。我决定对这些信号分子的框架形成机制进行功能阐明。

项目成果

Overexpression of CRKII increases migration and invasive potential in oral squamous cell carcinoma

• DOI: 10.1016/j.canlet.2011.01.004
• 发表时间: 2011-04-28
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Yamada, Shin-ichi;Yanamoto, Souichi;Nemoto, Takayuki K.
• 通讯作者: Nemoto, Takayuki K.

Regulation of Tcf7 by Runx2 in chondrocyte maturation and proliferation

• DOI: 10.1007/s00774-010-0222-z
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF BONE AND MINERAL METABOLISM
• 影响因子: 3.3
• 作者: Mikasa, Masaki;Rokutanda, Satoshi;Komori, Toshihisa
• 通讯作者: Komori, Toshihisa