Epidemiological study and risk analysis on zoonotic diseases in Asian countries

亚洲国家人畜共患病流行病学研究及风险分析

基本信息

批准号：
16255013
负责人：
MAKINO Sou-Ichi
金额：
$ 27.71万
依托单位：
Obihiro University of Agriculture and Veterinary Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16255013/
关键词：
Zoonosis Epidemiology Asian countries Animal hygiene Food hygiene

项目摘要

The purpose: By a wide-ranging movement of the person and food according to the world-wide borderlessness, various infectious diseases might spread widely. The, terrorism issue is added too, resulting that an international prevention for the infectious diseases should be essential Because it becomes big social issues if these infectious diseases invade Japan, it is necessary to collect various information for the infectious diseases in foreign countries and to strengthen the governmental crisis- management system. In addition, the risk analysis associated with the food -borne diseases would be essential. Since most of them are zoonotic diseases, a special research group associated with the food hygiene. Therefore, we focus on the epidemiological studies of zoonotic diseases and food hygiene in Asia countries, and also on the development of their rapid detection methods.Results: By a collaborated research with Thailand, we collected various foods as chicken meats, pig meats, beef meats, … More scrimps and oyster, to check their contamination by food pathogens like Salmonella, Campylobacter, Listeria, E. coli and etc. Also, we studied on their antibiotic resistance. As the results, the situation of the contamination showed same with Japan. Moreover, the recombination NP protein of avian influenza virus in E. coli was made and the latex agglutination methods to detect the virus antbody, in order to study its effect and availability in Asian countries. The method is available to detect influenza virus A antibody among all animals. However, there is no problem in avian serum, but since the non-specific reaction was occurred in duck serum, we could not remove the background. We are trying to start the epidemiological study in the Asian countries. In addition, the epidemiological surveillance concerning the infection history of toxoplasmosis among human and animals was done by the latex agglutination assay in Vietnam where the pig farming was main, resulting that the positive rate of the toxoplasmosis antibody rose in pig with the age, and the pig of about 70 percent or more was positive at the shipment stage, and the antibody possession rate was high. However, the antibody possession rate in human was lower in Japan. Finally, we studied on the hygienic situation in the slaughter houses in Vietnam, resulting that the situation was more serious than one Japanese, situation and that the immediate hygienic countermeasure would be essential in the country. Less

其目的是：由于世界范围内的无国界性，人员和食物的广泛流动，各种传染病可能会广泛传播，此外还增加了恐怖主义问题，因此必须对传染病进行国际预防。如果这些传染病入侵日本，将成为重大社会问题，有必要收集国外传染病的各种信息并加强政府危机管理系统，此外，与食源性疾病相关的风险分析也将成为可能。由于其中大多数是人畜共患疾病，因此，我们成立了一个与食品卫生相关的专门研究小组，重点开展亚洲国家人畜共患疾病和食品卫生的流行病学研究，并开发其快速检测方法。结果：通过与泰国的合作研究，我们收集了相关信息。各种食品，如鸡肉、猪肉、牛肉、虾仁和牡蛎，检查其是否被沙门氏菌、弯曲杆菌、李斯特菌、大肠杆菌等食物病原体污染。此外，我们对它们的抗生素耐药性进行了研究，结果显示污染情况与日本相同，并且制备了禽流感病毒在大肠杆菌中的重组蛋白，并采用乳胶凝集法检测病毒抗体。研究其在亚洲国家的效果和可用性。该方法可用于检测所有动物中的甲型流感病毒抗体。但是，在禽类血清中没有问题，但由于在鸭血清中出现非特异性反应，因此我们无法检测。删除背景。我们正在尝试在亚洲国家开展流行病学研究，另外，在以养猪业为主的越南，通过乳胶凝集试验进行了人畜弓形虫病感染史的流行病学监测，结果阳性率较高。猪体内的弓形体抗体随着年龄的增长而上升，约70%以上的猪在出厂阶段呈阳性，抗体拥有率较高，但日本人的抗体拥有率较低。最后，我们研究了越南屠宰场的卫生状况，发现情况比日本的情况还要严重，因此该国必须立即采取卫生对策。