ANALYSIS OF THE RELATIONSHIP BETWEEN THE EXPRESSION OF CYTOKINE GENES IN LEUKEMIA CELLS AND THE PROGNOSIS OF ACUTE LEUKEMIA PATIENTS.

白血病细胞中细胞因子基因的表达与急性白血病患者预后的关系分析。

基本信息

批准号：
06672288
负责人：
NARA Nobuo
金额：
$ 1.41万
依托单位：
TOKYO MEDICAL AND DENTAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06672288/
关键词：
acute myelogenous leukemia cytokines leukemic blast progenitors self-renewal G-CSF GM-CSF IL-3

项目摘要

The treatment of acute myelogenous leukemia has recently made marked progress. Many patients, however, can not survive longer than 5 years. To improve the prognosis of acute myelogenous leukemia, optimal therapy should be chosen for each patient based on his or her prognosis. The prognosis, therefore, is required to be assessed for each patient.The indefinite proliferation of leukemia cells in acute myelogenous leukemia patient is supported by a small subpopulation of leukemic blast progenitors with self-renewal capacity. We studied the proliferative activities of leukemic blast progenitors in ninety-five acute myelogenous leukemia patients. The self-renewal capacities of leukemic balst progenitors were varied among the patients. We found the significant relationship between the blast self-renewal capacity and the prognosis of patient. This suggests that the self-renewal capacity of leukemic blast progenitors is an useful marker to assess the patient prognosis.The proliferation of leukemic blast progenitors was found to be regulated by several cytokines, including G-CSF,CM-CSF,IL-3 and SCF.mRNAs of these cytokines were expressed in leukemia cells of several patients. This finding indicates the autocrine growth of leukemic blast progenitors. The relationship between the expression of cytokine genes and the patient prognosis was not significant.In conclusion, the biological nature of leukemic blast progenitors indicates the prognosis of acute myelogenous leukemia patients. To further improve the prognosis of leukemia patients, the development of the therapy eradicating leukemic blast progenitors is urgently required.

急性骨髓性白血病的治疗最近取得了明显的进展。但是，许多患者无法生存超过5年。为了改善急性粒细胞性白血病的预后，应根据患者的预后为每个患者选择最佳疗法。因此，需要为每位患者评估预后。急性粒细胞性白血病患者的白血病细胞无限期的增殖得到了对自我更新能力的白血病爆炸祖细胞的小群的支持。我们研究了95例急性脊髓骨髓性白血病患者中白血病爆炸祖细胞的增生活性。患者的白血病BALST祖细胞的自我更新能力各不相同。我们发现爆炸自我更新能力与患者预后之间的显着关系。这表明，白血病爆炸祖细胞的自我更新能力是评估患者预后的有用标记。发现白血病爆炸祖细胞的增殖受到多种细胞因子的调节，包括G-CSF，CM-CSF，CM-CSF，IL-3和SCF.MRNA，这些细胞因子在Leukemia细胞中表现出的这些细胞中的细胞中有几个患者。这一发现表明白血病爆炸祖细胞的自分泌生长。细胞因子基因的表达与患者预后之间的关系并不显着。总而言之，白血病性爆炸祖细胞的生物学性质表明急性脊髓性白血病患者的预后。为了进一步改善白血病患者的预后，迫切需要消除白血病爆炸祖细胞的疗法的发展。