The control of gastrointestinal motility in the chichen by the nutrients

营养物质对鸡胃肠蠕动的控制

基本信息

批准号：
06660352
负责人：
FURUSE Mitsuhiro
金额：
$ 1.28万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

项目摘要

The mechanism by which medium chain triacylglycerol (MCT) delayd the crop emptying rate in the chicken was investigated. The effect of administration route of MCT was determined. After oral or intraperitoneal administration of saline, MCT or long chain triacylglycerol (LCT), the crop emptying rate was measured. Only oral administration of MCT delayd the crop emptying compared with other treatments. The influence of alkaline treatment on the delayd crop emptying induced by MCT was investigated to clarify the involvement of acidity. The alkaline treatment did not improve the crop emptying and the highest treatment of alkaline further delayd the crop emptying rate. The involvement of dopaminergic or sympathetic neuron was invesetigated. The involvement of dopaminergic action was negligible, but the block of sympathetic neuron further delayd the crop emptying. The role of cholinergic mechanisms was investigated. Vagotomy altered the crop emptying of chicks given LCT,but did not alter it in chicks given MCT.Denervation in the cranial rete and lateral commisure of the gizzard further inhibited the food passage induced by MCT.Administration of cisapride, which induces acetylcholine release from the myenteric nerves, and atropine, a muscarinic cholinergic antagonist, both delayd crop emptying of chicks given medium chain triacylglycerol. These results demonstrate that cholinergic factors are not involved in the delayd forward movement of the food containing MCT from the crop of chicks. The effect of sodium nitroprusside (SNP), a spontaneous nitric oxide releaser, on the forward passage of the crop contents of chicks receiving MCT was studied. Crop emptying rate was significantly delayd as dietary SNP increased.

研究了中链三酰甘油（MCT）延迟鸡嗉囊排空率的机制。确定MCT给药途径的效果。口服或腹腔注射生理盐水、MCT或长链三酰甘油(LCT)后，测量嗉囊排空率。与其他治疗相比，仅口服 MCT 可以延迟嗉囊排空。研究了碱处理对 MCT 引起的作物排空延迟的影响，以阐明酸度的参与。碱处理并没有改善作物排空，并且最高碱处理进一步延迟了作物排空速率。研究了多巴胺能或交感神经元的参与。多巴胺能作用的参与可以忽略不计，但交感神经元的阻滞进一步延迟了嗉囊排空。研究了胆碱能机制的作用。迷走神经切断术改变了给予 LCT 的雏鸡嗉囊排空，但没有改变给予 MCT 的雏鸡。颅网和肌胃外侧连合的去神经进一步抑制了 MCT 诱导的食物通过。给予西沙必利，诱导乙酰胆碱从肌间神经和阿托品（一种毒蕈碱胆碱能拮抗剂）均能延迟雏鸡嗉囊排空，给予中链三酰甘油。这些结果表明，胆碱能因子与含有 MCT 的食物从雏鸡嗉囊中的延迟向前移动无关。研究了硝普钠 (SNP)（一种自发性一氧化氮释放剂）对接受 MCT 的雏鸡嗉囊内容物向前传播的影响。随着日粮 SNP 的增加，作物排空速度显着延迟。