Analysis of voluntary movement mechanism using transcranial magnetic stimulation

经颅磁刺激随意运动机制分析

• 批准号: 04680127
• 负责人: KASAI Tatsuya
• 金额: $ 1.15万
• 依托单位: HIROSHIMA UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04680127/
• 关键词: Motor cortex; Voluntary movement; H-reflex; Magnetic stimulanion; MEP; Reaction response; Human; spinal reflex; 随意運動; H反射; 経頭蓋的磁気刺激; 筋電図; 磁気刺激; ヒト; 大脳運動野

We recorded motor evoked potentials (MEPs) and H-reflexes from, flexor carpi radialis (FCR) muscle of eight normal adult subjects.Subiects were either at rest, or with the target muscle voluntarily contracted (10% max). A magnetic coil was used to deliver 20-30 stimuli and MEPs were recorded. H-reflexs were elicited by electrical stimulation of the median nerve (20-30 stimuli, 0.5-1.0 ms duration). The variability in amplitude, duration and area size of potentials was studied as excitability of human hand muscle motoneurons changed. The results were used to estimate whether MEP amplitude and H-reflex amplitude were an optimal index of excitability changes in the postsynaptic potentials of the human motoneuron pool. The variability in amplitude, duration and area size of the MEP were large than those of the H-reflex. Furthermore, there was a difference in the regression coefficient for amplitude and area size between H-reflex and MEP.These results indicate that there are differnt neurophysilogical mechanisms related to the production of excitatory postsynaptic potentials for the H-reflex and MEP,respectively.

我们记录了来自八个正常成人受试者的屈肌腕radialis（FCR）肌肉的诱发电势（MEP）和H反射。取消静止或目标肌肉自愿收缩（最大10％）。使用磁线圈传递20-30个刺激，并记录MEP。通过电刺激中位神经（20-30刺激，持续时间为0.5-1.0 ms），引起H反射。随着人手肌肉运动神经元的兴奋性改变，幅度，持续时间和电位面积大小的变化进行了研究。结果用于估计MEP振幅和H反射幅度是否是人类运动神经池突触后电位的兴奋性变化的最佳指标。 MEP的幅度，持续时间和面积大小的变化大于H反射的变化。此外，H反射和MEP之间的振幅和面积大小的回归系数有所不同。这些结果表明，与H-Reflex和MEP的兴奋性突触后潜能的产生有关的神经生理学机制有所不同。

项目成果

笠井達哉: "反応時間法とH反射法を使ったヒト随意運動機能の解析" Japanese Journal of Sports Sciences. 13. 131-142 (1994)

Tatsuya Kasai：“使用反应时间法和 H 反射法分析人体自主运动功能”日本运动科学杂志 13. 131-142 (1994)。

笠井達哉: "ヒトの経頭蓋的大脳皮質刺激法" Japanese Journal of Sports Sciences. 12. 54-70 (1993)

Tatsuya Kasai：“人体经颅大脑皮层刺激”《日本运动科学杂志》12. 54-70 (1993)。

笠井達哉: "反応時間法とH反射法を使ったヒト随時運動機の解析" Japanese Journal of Sports Sciences. 13. 131-142 (1994)

Tatsuya Kasai：“使用反应时间法和 H 反射法分析人体自主运动”《日本运动科学杂志》13. 131-142 (1994)。

Kasai, T. :"An Analysis of Human Voluntary Movement by Reaction Time and H-reflex Technique." Japanese Journal of Sports Sciences. 13. 131-142 (1994)

Kasai, T.：“通过反应时间和 H 反射技术分析人类自主运动。”

笠井 達哉: "ヒトの経頭蓋的大脳皮質刺激法" Japenese Journal of Sports Science. 12. 54-70 (1993)

Tatsuya Kasai：“人体经颅大脑皮层刺激”日本运动科学杂志 12. 54-70 (1993)。