Twin screw extruder

双螺杆挤出机

基本信息

批准号：
439400908
负责人：
金额：
--
依托单位：
Technische Universität Braunschweig
依托单位国家：
德国
项目类别：
Major Research Instrumentation
财政年份：
2020
资助国家：
德国
起止时间：
2019-12-31 至无数据
项目状态：
未结题

来源：
https://gepris.dfg.de/gepris/projekt/439400908?language=en
关键词：
Twin screw extruder

项目摘要

At the Center of Pharmaceutical Engineering (PVZ) at TU Braunschweig, scientists from the Faculties of Mechanical Engineering and Life Sciences, in particular from the fields of process engineering, pharmacy as well as micro and production technology, work interdisciplinary on joint research projects. The aim of the center is to develop and characterize efficient formulation strategies as well as manufacturing and processing methods for challenging active pharmaceutical ingredients by bundling the expertise from the participating disciplines. Special attention is paid to active substances with difficult processing properties such as those with poor solubility or sensitive biomolecular structure. With regard to important future issues, major topics of interest also include continuous production and the development of individualized medicines. With the extruder applied for, it is intended to establish a central technology at the PVZ for these research objectives. The device is to be used, among others, for the development of novel, extrusion- and granulation-based dosage forms, in particular for efficient and individualized therapy. In this context, a deep understanding of process-structure-property relationships in extrusion and granulation as well as in downstream operations is going to be developed. This involves research on methods for process and product monitoring in order to define rationally derivable process limits and process-quality-correlations as well as the development of simulation methods for the elucidation of underlying microprocesses.

在布伦瑞克工业大学的制药工程中心 (PVZ)，来自机械工程和生命科学学院的科学家，特别是来自工艺工程、制药以及微型和生产技术领域的科学家，跨学科开展联合研究项目。该中心的目标是通过整合参与学科的专业知识，开发和表征有效的配方策略以及具有挑战性的活性药物成分的制造和加工方法。特别关注具有难以加工特性的活性物质，例如溶解度差或生物分子结构敏感的活性物质。关于未来的重要问题，人们感兴趣的主要话题还包括连续生产和个体化药物的开发。通过申请挤出机，旨在为这些研究目标在 PVZ 建立一项核心技术。该设备将用于开发新型的、基于挤出和造粒的剂型，特别是用于高效和个体化的治疗。在此背景下，将深入了解挤出和造粒以及下游操作中的工艺-结构-性能关系。这涉及对过程和产品监控方法的研究，以定义合理推导的过程限制和过程质量相关性，以及开发用于阐明底层微过程的模拟方法。