Diagnostic and Nosological Study on Developmental Disorders Related to Infantile Autism

婴儿自闭症相关发育障碍的诊断和疾病学研究

基本信息

批准号：
63480263
负责人：
KURITA Hiroshi
金额：
$ 1.98万
依托单位：
National Center of Neurology and Psychiatry
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1990
项目状态：
已结题

项目摘要

To conduct this study, we developed three rating scales. The first one, the Childhood Autism Rating Scale--Tokyo Version (CARS-TV) demonstrated satisfactory taxonomic validity on DSM-III diagnostic groups. Cronbach's alpha was .87. An average interrater reliability (r) was .62. The next, the Tokyo Autistic Behavior Scale (TABS) showed a satisfactory test-retest reliability (r for the total score was .94). Cronbach's alpha was .78. The total TABS score was significantly higher in infantile autism (IA) than in other five DSM-III groups. A value of r between total scores of the TABS and the CARS-TV was .59. The third, the Checklist for Autistic Tendency (CAT) showed satisfactory split-half reliability and concurrent validity to the DSM-III groups.The total CARS-TV score was significantly lower in 57 Other Pervasive Developmental Disorders (OPDDs) than in 39 IAs. OPDDs were significantly less impaired than IAs in two CARS-TV scales : Visual responsiveness and general impressions. The total and nine item TABS scores indicated that OPDD was significantly less impaired than IA.Development before regression was better in 15 disintegrative psychosis (DP) cases than sex- and age-matched 30 IAs having had similar regression. But it was not entirely normal in more than half of the DPs as some of such historical cases. After regression, DPs had significantly lower mental development level than IAs. The total CARS-TV score did not differ significantly between DPs and IAs. We suggested a phrase "apparent normal development" before regression in the diagnostic criteria for disintegrative disorder (a new name for DP) in ICD-10 draft be replaced with "normal or near normal development." Although OPDD seems milder in intellectual and autistic impairments than IA, it is still a mixture of diverse conditions that need more precise division.

为了进行这项研究，我们开发了三个评分量表。第一个是儿童自闭症评级量表 - tokyo版本（CARS-TV）对DSM-III诊断组表现出令人满意的分类有效性。克朗巴赫的alpha为.87。平均跨层可靠性（R）为0.62。接下来，东京自闭症行为量表（TABS）显示出令人满意的测试可靠性（总分的R为0.94）。克朗巴赫的alpha为.78。婴儿自闭症（IA）的总选项卡得分明显高于其他五个DSM-III组。 TABS总分和CARS-TV之间的R值为.59。第三，自闭症趋势（CAT）的清单显示出令人满意的半分裂可靠性和对DSM-III组的同时有效性。其他57个其他普遍发育障碍（OPDDS）的总CARS-TV得分明显低于39 IAS中的其他57个。在两个CARS-TV量表中，OPDD的损害明显少于IAS：视觉反应性和一般印象。总数和九项选项卡的得分表明，OPDD在15个崩解性精神病（DP）病例中的回归之前的开发要好于与性别和年龄匹配的30个IAS相似的回归的发展。但是，在某些历史案例中，在DP的一半以上，这并不是完全正常的。回归后，DPS的心理发展水平明显低于IAS。 DPS和IAS之间的CARS-TV得分没有显着差异。我们建议在ICD-10草案中脱离障碍诊断标准（DP的新名称）回归之前，提出了“明显的正常发展”一词，被“正常或接近正常发育”代替。尽管OPDD在智力和自闭症障碍方面似乎比IA较温和，但它仍然是需要更精确分裂的各种条件的混合体。