A clinical study on symptoms, development and course of childhood disintegrative disorders

儿童崩解性疾病症状、发展和病程的临床研究

基本信息

批准号：
09670977
负责人：
KURITA Hiroshi
金额：
$ 1.98万
依托单位：
UNIVERSITY OF TOKYO
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

To study clinical validity of DSM-IV childhood disintegrative disorder (CDD), 10CDD children (M=7.7 years ; 7 male, 3 female), 11 (M=6.5 years ; 9 male, 2female) with ICD-9 disintegrative psychosis (DP) diagnosed as DSM-IV autistic disorder (AD)(DP-AD), 7 (M=6.1 years ; 5 male, 2 female) with DP diagnosed as DSM-IV PDDNOS (DP-PDDNOS), and 82 (M=5.9 years ; 62 male, 20 female) with AD with speech loss (ASL) were compared on 16, 8, and 24 variables before, during, and after regression, respectively. Among the 4 groups without significant difference in age and sex ratio, 12 variables showed a significant difference by post hoc comparisons. Before regression, CDD was significantly stronger in separation anxiety around age one than ASL, more common to use finger pointing than DP-PDDNOS and ASL, and better in bladder control than DP-AD and ASL.ASL was significantly less frequent to use a two-word phrase and earlier to lose speech than the other 3, and less common in normal relationship than CDD and DP-AD.During regression, CDD significantly more frequently lost finger pointing than ASL and bladder control than DP-AD and ASL.ASL showed significantly less commonly fearfulness than the other 3. After regression, CDD showed epilepsy and stereotypy significantly more frequently than ASL.DP-PDDNOS showed significantly milder verbal communication disturbance than ASL.The autistic tendency and rate of children with IQ<35 did not differ significantly among the 4 groups. Although CDD was better in development before regression and clearer in regression, its difference in development and autistic tendency from ASL disappeared and its differences from DP-AD and DP-PDDNOS decreased about 4 years after regression. CDD has clinical validity. Its developmental outcome may not be different from that of ASL occupying 20 to 40 % of the autism population.

研究DSM-IV儿童期崩解障碍（CDD）的临床有效性，10CDD儿童（M = 7.7岁； 7名男性，3位女性），11（M = 6.5岁； 9个男性，2female），ICD-9分解精神病（DP））被诊断为DSM-IV自闭症（AD）（DP-AD），7（M = 6.1岁； 5个男性，2个女性），DP被诊断为DSM-IV PDDNOS（DP-PDDNOS）和82（M = 5.9）在16、8和24个变量上，分别比较了62名男性，20个女性，分别在16、8和24个变量中进行了比较。在年龄和性别比没有显着差异的4组中，有12个变量显示出事后比较的显着差异。在回归之前，CDD的分离焦虑症年龄较大，比ASL明显更强，使用指向的指向比DP-PDDNOS和ASL更为常见，并且在膀胱控制方面比DP-AD和ASL.ASL更频繁地使用两个频率。 - 单词短语，比其他3个言语更早，在正常关系中比CDD和dp-ad.dp-ad。的回归少于ASL和膀胱控制的频率要比DP-AD和ASL显示出的频率更高。与其他3相比，比其他3。在回归后，CDD表现出癫痫和刻板印象的频率明显高于ASL.DP-PDDNOS与ASL相比，表现出明显较小的口头交流障碍。在四个组中。尽管CDD在回归之前的发展状况较好，并且在回归方面更清晰，但其发育和自闭症趋势的差异消失了，其与DP-AD和DP-PDDNOS的差异在回归后大约4年减少。 CDD具有临床有效性。它的发展结果可能与占有自闭症患者20％至40％的ASL的结果可能没有什么不同。