Changes of gustatory system through life time

一生中味觉系统的变化

• 批准号: 62480382
• 负责人: KASAHARA Yasuo
• 金额: $ 4.29万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1987
• 资助国家: 日本
• 起止时间: 1987 至 1989
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-62480382/
• 关键词: Development; Taste buds; Chorda tympani; Gustatory response; Rat; development; taste buds; chorda tympani; gustatory response; rat; 味覚受容の成長変化; 糖受容器と交叉順応; 糖受容器と蛋白分解酵素; 単一味神経線維の糖応答; 味蕾の成長発育; 味神経応答の成長変化; 各種糖類に対する鼓索神経応答の成長変化; 味蕾; 鼓索神経; 各種糖類

CHANGES OF GUSTATORY SYSTEM THROUGH LIFE TIME.In order to clarify changes of gustatory system through life time, histological and electrophysiological experiments were performed in the rat. Histological examination on the anterior tongue innervated by chorda tympani nerve showed that the ratio of matured taste buds which possess a taste pore were only 9% of all taste buds observed at 1 week of postnatal age, and 81.3% at 3 weeks of age. Recording integrated responses from the chorda tympani nerve reveals that taste buds with a pore at 1 week of age responded to NaCl, HCl, and quinine-HCl as well as in adult rats, which suggests that these relatively young taste buds are matured functionally for these three stimuli.However, the response magnitudes for various sugars at 1 week of age were smaller compared to those in the adult rat, reached to the maximum at 3 weeks of age, then decreased gradually with age. Also, results from the experiment of cross-adaptation among different sugars, effects of pronase-E treatment of the tongue, analysis of correlation between on- and off-responses to sugars, showed that qualitative changes for sugar responses continues after 3 weeks of age. These results suggest that functional changes occur in the gustatory processing of sugars during postnatal development in the rat chorda tympani nerve.

为了通过终生阐明味觉系统的变化，在大鼠中进行了组织学和电生理实验。在丘巴鼓神经支配的前舌上的组织学检查表明，拥有味道孔的成熟味蕾的比率仅占产后1周的所有味蕾的9％，在3周龄时观察到81.3％。记录丘巴鼓神经的集成反应表明，味蕾在1周大的时候回应了毛孔，对NaCl，HCl和Quinine-HCl以及成年大鼠响应，这表明这些相对年轻的味蕾在这三个刺激上的最大成年糖的最大成年人比较成年，这表明这些相对年轻的味蕾在功能上成熟。年龄，然后随着年龄的增长而逐渐减少。同样，不同糖之间交叉适应的实验的结果，对舌头的下碱治疗的影响，对糖的反响应和反响应之间的相关性的分析表明，糖反应的质量变化在3周大3周后持续。这些结果表明，在大鼠鼓膜神经的产后发育过程中，糖的味道加工发生了功能变化。

项目成果

Maeda, S., Harada, S. and Kasahara, Y.: "Developmental changes in gustatory responses of rat chorda tympani nerve." Proc. 21st Jap. Symp. on Taste & Smell 21, 161-164, 1987.

Maeda, S.、Harada, S. 和 Kasahara, Y.：“大鼠鼓索神经味觉反应的发育变化。”

Harada,S.,Maeda,S.and Kasahara,Y.: "Sugar response characteristics in the rat chorda tympani nerve during development." Abstracts of Xlth Annual Meeting of the Association for Chemoreception Sciences. 11. 9 (1989)

Harada, S.、Maeda, S. 和 Kasahara, Y.：“大鼠鼓索神经发育过程中的糖反应特征。”

Harada,S.,Maeda,S.and Kasahara,Y.: "Sugar response characteristics in the rat chorda tympani nerve during development." Chemical Senese. 14. 707-708 (1989)

Harada, S.、Maeda, S. 和 Kasahara, Y.：“大鼠鼓索神经发育过程中的糖反应特征。”

Harada,S.;Maeda,S.;Kasahara,Y.: Proceedings of the 21st Japanese Symposium on Taste and Smell. 21. 165-168 (1987)

原田，S.；前田，S.；笠原，Y.：第 21 届日本味觉和嗅觉研讨会论文集。

Maeda, S.: "Developmental changing of rat taste responses from chorda tympani nerve." J. Physiol. Soc. Jap. 52(3), 67-83, 1990.

Maeda, S.：“大鼠鼓索神经味觉反应的发育变化。”