Study on dental alloys to clarify the mechanism of allergy

研究牙科合金以阐明过敏机制

• 批准号: 05671631
• 负责人: FURUKAWA Kazutoshi
• 金额: $ 1.34万
• 依托单位: Iwate Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671631/
• 关键词: Metal Allergy; Functional Measurement of Electrode Potential; Penetration of Metallic Ions; 歯科用合金

In order to clarify the mechanism of allergy, functional measurements of the electrode potential within the oral cavity were undertaken. This method involved measuring the metallic ion penetration of the various dental alloys within the oral cavity. The alloys measured were Co, Cr, Ni, and Sn which are considered to be dental materials having a high allergy rate, and were in turn compared to the low allergy rate dental alloys of Au and Au-Ag-Pd. The experiment involved 4 male subjects having either a full cast crown on the premolar or molar region. The functional condition included 3 type of measurements, 1) during the rest position, 2) lateral movement, and 3) with a pH3.75 solution in the mouth. Results showed that for Ni-Cr alloy, the electric potential changed from -63.9--325.7mV during rest position, -82.0--365.3mV during lateral movement, and -92.4--396.7mV with the solution. For Co-Cr alloy, the electric potential changed from -134.3--4.115mV during rest position, -181.7--434.0mV during lateral movement, and -279.3--427.7mV with the solution. Ag alloy showed the electric potential to change from -154.8--288.4mV during rest position, -191.2--308.7mV during lateral movement, and -234.2--376.8mV with the solution. The electric potential for Au-Ag-Pd alloy changed from +51.4--135.0mV during rest position, +51.8--138.3mV during lateral movement, and -27.0--238.4mV with the solution. For Au alloy, the electric potential changed from +25.0--103.9mV during rest position, +21.4--132.0mV during lateral movement, and -35.6--226.2mV with the solution . In conclusion, it can be said that the functional measurments of electrode potential for the dental materials showed penetration of metallic ions.

为了阐明过敏机制，对口腔内的电极电位进行了功能测量。该方法涉及测量口腔内各种牙科合金的金属离子渗透率。测量的合金是Co、Cr、Ni和Sn，它们被认为是具有高过敏率的牙科材料，并且依次与Au和Au-Ag-Pd的低过敏率牙科合金进行比较。该实验涉及 4 名男性受试者，他们的前磨牙或磨牙区域有全铸冠。功能条件包括 3 种类型的测量，1）在休息位置期间，2）横向运动，以及 3）口腔中含有 pH3.75 溶液。结果表明，对于Ni-Cr合金，静止位置时电位变化为-63.9--325.7mV，横向移动时电位变化为-82.0--365.3mV，溶液中电位变化为-92.4--396.7mV。对于Co-Cr合金，静止位置时电位变化为-134.3--4.115mV，横向移动时电位变化为-181.7--434.0mV，溶液时电位变化为-279.3--427.7mV。银合金显示静止位置时电势从-154.8--288.4mV变化，横向移动时电势变化-191.2--308.7mV，溶液中电势变化-234.2--376.8mV。 Au-Ag-Pd合金的电位在静止位置时从+51.4--135.0mV变化，在横向移动时变化为+51.8--138.3mV，在溶液中变化为-27.0--238.4mV。对于Au合金，静止位置时电位变化为+25.0--103.9mV，横向移动时电位变化为+21.4--132.0mV，溶液变化为-35.6--226.2mV。总之，可以说，牙科材料的电极电位的功能测量显示出金属离子的渗透。

项目成果

松田もと子: "パッチテストによる皮膚反応の色彩学的分析" 日本補綴歯科学会雑誌. 38. 588-595 (1994)

Motoko Matsuda：“通过斑贴试验进行皮肤反应的色彩分析”日本修复医学会杂志 38. 588-595 (1994)。

Motoko Matsuda, et al: "Colormetric Analysis of the Skin Reaction by Patch Test" J,Jpn Prosthodont Soc. 38. 588-595 (1994)

Motoko Matsuda 等人：“通过斑贴试验对皮肤反应进行比色分析”J，Jpn Prosthodont Soc。