Effects of cyclosporin, azathioprine and mizoribin on male reproduction in rats

环孢素、硫唑嘌呤和咪唑立宾对雄性大鼠生殖的影响

• 批准号: 05671306
• 负责人: IWASAKI Masashi
• 金额: $ 1.28万
• 依托单位: TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05671306/
• 关键词: immunosuppresive drug; cyclosporine (Cs); azathioprine (AZP); mizoribin (MZR); spermatogenesis; rat; cyclosporin; 精細管障害; アザチオプリン; ミゾリビン; 精子運動率

The effects of cyclosporin (Cs) , azathioprine (AZP) and mizoribin (MZR) on male reproduction in rats were examined.A dose-dependent decrease in the sperm count in the cauda epididymis was observed 6 weeks after Cs, AZP and MZR were administered. Sperm motility was significantly decreased in each Cs-treated group immediately after the injection of Cs and improved gradually, but was not changed in the AZP or MZR treated groups.Significant dose-dependent damage of the seminiferous tubules was demonstrated 6 weeks after administration of Cs, AZP and MZR.The serum levels of luteinizing hormone and follicle-stimulating hormone remained the same throughout the experiment. The serum level of testosterone was significantly low immediately after the injections of AZP and MZR,but was not changed by that of Cs.In conclusion, Cs, AZP and MZR injured the spermatogonia in rat, but only Cs injured the epididymal function as well.

研究了环孢素（Cs）、硫唑嘌呤（AZP）和咪唑立宾（MZR）对大鼠雄性生殖的影响。在给予Cs、AZP和MZR后6周，观察到附睾尾部精子数量呈剂量依赖性下降。 。注射Cs后，每个Cs治疗​​组的精子活力均显着下降，并逐渐改善，但AZP或MZR治疗组没有变化。注射Cs后6周，显示出显着的剂量依赖性生精小管损伤、AZP和MZR。在整个实验过程中，黄体生成素和卵泡刺激素的血清水平保持相同。注射AZP和MZR后血清睾酮水平明显降低，但Cs未改变血清睾酮水平。综上所述，Cs、AZP和MZR损伤大鼠精原细胞，但只有Cs也损伤附睾功能。