Study on the prognostic factors in the pediatric patients with arrhythmias using coronary sinus canulation, electrophysiologic study and endomyocardial biopsy

冠状窦插管、电生理检查及心内膜心肌活检对小儿心律失常患者预后影响的研究

• 批准号: 05670650
• 负责人: YONESAKA Susumu
• 金额: $ 1.34万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670650/
• 关键词: Arrhythmia; Endomyocardial biopsy; Coronary sinus canulation; Electrophysiological study; Cardiac metabolism; 洞結節電位(SNE)

In order to evaluate myocardial histopathology in the patients with supraventricular tachycardia (SVT), eleven patients with SVT have been studied. These patients were divided into two groups with respect to the type of SVT ; group I was incessant SVT,group II was paroxysmal supraventricular tachycardia. Although there were no significant abnormalities in clinical and hemodynamic parameters in group II,three patients had clinical feature of dilated cardiomyopathy with abnormal ECG,chest X-P and hypokinesis on left ventriculogram in group I.Induction and termination of SVT were able to achieve in two patients of group I and in four out of six patients of group II.High incidence of histopathological abnormalities, such as hypertrophy, degeneration, interstitial fibrosis and disarray were noticed in both groups. The incidence of significant pathology was higher in group I than in group II.Our present recommendations are to perform not only intracardiac electrophysiologic study of patients with SVT who have incessant or recurrent type of SVT but also endomyocardial biopsy to evaluate myocardial demage, because SVT might be the initial sign of cardiomyopathy.As far as ventricular arrhythmias were concerned, the origin of the ventricular arrhythmia was higher in right ventricle than in the left ventricle. There was no significant difference between the clinical features and origin of the ventricular arrhythmias. About 15% of patients with ventriular arrhythmias had myocardial involvement such as cardiomyopathy or myocarditis. It is considered that proper treatment for the ventricular arrhythmias could prevent further development of myocardial demages due to prolonged tachyarrhythmias.

为了评估室上性心动过速 (SVT) 患者的心肌组织病理学，对 11 名 SVT 患者进行了研究。这些患者根据 SVT 类型分为两组； I组为持续性SVT,II组为阵发性室上性心动过速。虽然II组临床及血流动力学参数无明显异常，但I组有3例患者具有扩张型心肌病临床特征，心电图、胸部X-P异常、左心室运动功能减退，其中2例患者能够实现SVT的诱导和终止。 I 组的 6 名患者中有 4 名出现这种情况，II 组的 6 名患者中有 4 名出现这种情况。两组均观察到组织病理学异常发生率较高，如肥大、变性、间质纤维化和紊乱。 I 组显着病理的发生率高于 II 组。我们目前的建议不仅对持续或复发型 SVT 的 SVT 患者进行心内电生理学研究，而且还进行心内膜心肌活检以评估心肌损伤，因为 SVT 可能会导致心肌损伤。是心肌病的首发症状。就室性心律失常而言，室性心律失常的起源在右心室高于左心室。室性心律失常的临床特征和起源之间没有显着差异。约15%的室性心律失常患者有心肌受累，如心肌病或心肌炎。人们认为，对室性心律失常进行适当的治疗可以防止由于长时间的快速心律失常引起的心肌损伤的进一步发展。

项目成果

Susumu Yonesaka: "Studies on secondary forms of myocardial diseases with special references to endomyocardial biopsy in infants and children." Kokyu to Junkan. 43. 175-179 (1995)

Susumu Yonesaka：“对继发性心肌疾病的研究，特别是婴儿和儿童的心内膜心肌活检。”

米坂 勧: "心筋生検からみた小児期二次性心筋疾患の検討" 呼吸と循環. 43. 175-179 (1995)

Kan Yonezaka：“从心肌活检的角度调查儿童继发性心肌疾病”《呼吸与循环》43。175-179（1995）。