ENDOMYOCARDIAL BIOPSY FINDINGS IN LONG-TERM TREATMENT WITH AMIODARONE

胺碘酮长期治疗的心内膜心肌活检结果

• 批准号: 3843451
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843451
• 关键词: amiodarone; biopsy; drug administration rate /duration; drug adverse effect; heart cell; heart disorder chemotherapy; histopathology; human therapy evaluation; human tissue; inclusion body; lysosomes; muscle cells; myocardium disorder; vascular endothelium

This report describes ultrastructural changes in myocardium of 2 patients with dilated cardiomyopathy who had received long term treatment with amiodarone, a highly effective antiarrhythmic agent. Cardiac myocytes and endothelial cells in these two patients contained cytoplasmic inclusions that consisted of electron-dense concentric lamellae and were considered to represent altered lysosomes. These inclusions were morphologically similar to those occurring in other tissues in patients receiving long term therapy with amiodarone.

该报告描述了2例患者心肌的超微结构变化 患有扩张的心肌病，他接受了长期治疗 胺碘酮，一种高效的抗心律失常剂。心肌细胞和 这两个患者中的内皮细胞含有细胞质包含物 由电子密集的同心薄片组成，被认为 代表改变的溶酶体。 这些夹杂物在形态上相似 在接受长期治疗的患者中发生在其他组织中的患者 与胺碘酮。