Effect of Magnesium Deficiency on Immunoreaction

缺镁对免疫反应的影响

• 批准号: 04454217
• 负责人: KIMURA Mieko
• 金额: $ 0.45万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04454217/
• 关键词: nutritional status; magnesium deficiency; immunity; spleen cell; spleen T cell; macrophage; mitogene; cytokine; 免疫

Recently, with the changes of food habits and life styles, heart disease and cancer in Japan are increasing, and it is pointed out that good nutritional status will be very important to prevent of these diseases and to keep immunompetence. On the other hand, it is well known that magnesium plays the key role as an activator of nealy all enzymes, and under magnesium deficiency umbalance of these systems, such as, spleen hypertrophy, leukocytosis, lymphocyte abnomality, malfunction of neurotracmission, and changes in immune responses will be also expected.Spleen cells and macrophage (Mphi) from rats fed magnesium deficient diet and normal diet for 1 or 2 weeks were collected in this study. Mitogene(ConA, LPS) and cytokines(IL-2, IL-3) productions in spleen cells, and IL-1 and IL-6 productions in Mphi were measured. Response to ConA of spleen cells of magnesium deficient rats was markedly enhanced in the compared with those of normal rats. Il-2 value in spleen cells, and IL-1 and IL-6 productions in Mphi of magnesium deficient rats were slightly higher. In interaction of T cells of spleen and Mphi, response to ConA of Mphi of magnesium deficient rats was decreased compared to normal rats.

近年来，随着饮食习惯和生活方式的改变，日本心脏病和癌症日益增多，人们指出良好的营养状况对于预防这些疾病和保持免疫功能非常重要。另一方面，众所周知，镁作为几乎所有酶的激活剂起着关键作用，缺镁时这些系统会失衡，如脾肥大、白细胞增多、淋巴细胞异常、神经传导功能障碍、神经功能改变等。免疫反应也是预期的。本研究收集了喂食缺镁饮食和正常饮食 1 或 2 周的大鼠的脾细胞和巨噬细胞 (Mphi)。测量脾细胞中有丝分裂基因(ConA、LPS)和细胞因子(IL-2、IL-3)的产生，以及Mphi中IL-1和IL-6的产生。与正常大鼠相比，缺镁大鼠脾细胞对ConA的反应明显增强。缺镁大鼠脾细胞中的IL-2值以及Mphi中IL-1和IL-6的产生略高。在脾脏T细胞与Mphi的相互作用中，与正常大鼠相比，缺镁大鼠对Mphi ConA的反应降低。

项目成果

K.Murakami,M.Hosono 他: "Concomitant enhancement of the response to Mls-l^a antigens and the induction of postthymectomy autoimmune gastritis in BALB/c mice." Clin.Exp.Immunol.92. 500-505 (1993)

K. Murakami、M. Hosono 等人：“BALB/c 小鼠中对 Mls-1^a 抗原的反应的同时增强和胸腺切除后自身免疫性胃炎的诱导。”Clin.Exp.Immunol.92。 1993）

木村美恵子 横井克彦他: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" JJSMgR. 11. 19-29 (1992)

Mieko Kimura、Katsuhiko Yokoi 等：“由于铁摄入量差异导致缺镁大鼠血清生化特性的变化”JJSMgR 11. 19-29 (1992)。

K.Murakami,H.Maruyama: "Effects of intrathymicinjection of organ-specific autoantigens,parietal cells,at the neonatal stage on autoreactive effector and suppressor T call precursors." Eur.J.Immunol.23. 809-814 (1993)

K.Murakami、H.Maruyama：“在新生儿阶段，胸腺内注射器官特异性自身抗原、壁细胞对自身反应性效应子和抑制性 T 细胞前体的影响。”

木村 美恵子,横井 克彦 早瀬 稔,糸川 嘉則: "鉄摂取量の違いによるマグネシウム欠乏ラットの血清生化学性状の変化" マグネシウム(JJSMgR). 11. 19-29 (1992)

Mieko Kimura、Katsuhiko Yokoi、Minoru Hayase、Yoshinori Itokawa：“由于铁摄入量差异导致缺镁大鼠血清生化特性的变化”镁 (JJSMgR) 11. 19-29 (1992)。

K.Murakami,M.Hosono: "Concomitant enhancement of the response to Mls-1^a antigens and the induction of post-thymectomy autoimmune gastritis in BALB/c mice." Clin.Exp.Immunol.92. 500-505 (1993)

K.Murakami、M.Hosono：“同时增强 BALB/c 小鼠对 Mls-1^a 抗原的反应并诱导胸腺切除后自身免疫性胃炎。”