Functional proteomics dissection of chemotactic protein diversity (A13*)

趋化蛋白多样性的功能蛋白质组学剖析 (A13*)

• 批准号: 426908965
• 金额: --
• 依托单位: Institut für Angeborene Immunität
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 财政年份: 2019
• 资助国家: 德国
• 起止时间: 2018-12-31 至 2022-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/426908965?language=en
• 关键词: Functional; proteomics; dissection; chemotactic; protein

Chemotactic protein activity is regulated at multiple levels, including post-translational modifications. In this project, we will test the hypothesis that divergent paracrine activities arise from differentially modified chemotactic protein variants (proteoforms) by combining proteomics discovery technologies, systems biology and functional validation approaches. Thereby, we will establish a system-level view of chemokine proteoform diversity and will generate new insights about how paracrine signals and their modifications affect cell signaling and chemotaxis during tissue homeostasis and inflammation.

趋化蛋白活性在多个水平上受到调节，包括翻译后修饰。在该项目中，我们将测试以下假设：旁分泌活性是由差异修饰的趋化蛋白变异（蛋白质成型型）通过结合蛋白质组学发现技术，系统生物学和功能验证方法而产生的。因此，我们将建立趋化因子蛋白质多样性多样性的系统水平视图，并就组织体内平衡和炎症期间旁分泌信号及其修饰如何影响细胞信号传导和趋化性。