The effect of stress-related gene expression on nocturnal parafunction.

应激相关基因表达对夜间功能障碍的影响。

• 批准号: 25670826
• 负责人: HOSOKAWA Ryuji
• 金额: $ 2.41万
• 依托单位: Kyushu Dental College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670826/
• 关键词: ストレスマーカー; ベンゾジアゼピン; ブラキシズム; パラファンクション; 睡眠; 遺伝子多型; 睡眠時ブラキシズム; 精神的ストレス

Peripheral-type benzodiazepine receptor (PBR) gene polymorphism is associated with stress sensitivity, but it is not yet clear whether polymorphisms in this gene have any influence on psychological stress before and after sleep bruxism. The present study was performed to examine the relationship between sleep bruxism and PBR gene polymorphism. The PBR gene was amplified after collection of DNA from oral mucosa cells. Polymorphisms were identified by direct sequencing after PBR gene amplification by PCR. We also measured masseter muscle activity during sleep using portable electromyography to evaluate sleep bruxism. The number of bruxism events was significantly higher in the G/A than the G/G group. Changes in salivary CgA levels were significantly lower in the G/A than G/G group.

外周型苯二氮卓受体（PBR）基因多态性与压力敏感性相关，但尚不清楚该基因中的多态性在睡眠磨砂膏之前和之后是否对心理压力有任何影响。进行了本研究以检查睡眠磨牙症与PBR基因多态性之间的关系。从口服粘膜细胞收集DNA后，PBR基因被扩增。通过PCR扩增PBR基因后，通过直接测序鉴定了多态性。我们还使用便携式肌电图测量了睡眠期间的咬合肌肉活动，以评估睡眠磨牙症。 G/A中的磨牙症事件的数量明显高于G/G组。 G/A的唾液CGA水平的变化明显低于G/G组。

项目成果

Sleep bruxism is affected by peripheral benzodiazepine receptor gene polymorphisms

睡眠磨牙症受外周苯二氮卓受体基因多态性影响

• DOI: 10.1007/s12548-013-0101-z
• 发表时间: 2014
• 期刊: International journal of stomatology & occlusion medicine
• 作者: Takaya Murakami;Chihiro Masaski;Hidetaka Takahashi;Michiko Makino;Taro Mukaibo;Yusuke Kondo;Tetsuji Nakamoto;Ryuji Hosokawa
• 通讯作者: Ryuji Hosokawa