Establishment of mouse model of chronic mucocutaneous candidiasis disease and use them to find therapeutic target

慢性皮肤粘膜念珠菌病小鼠模型的建立及寻找治疗靶点

• 批准号: 25670477
• 负责人: OKADA Satoshi
• 金额: $ 2.33万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25670477/
• 关键词: STAT1; CMCD; IL-17; マウス; ノックインマウス; 治療

项目成果

Infectious disease. Life-threatening influenza and impaired interferon amplification in human IRF7 deficiency.

• DOI: 10.1126/science.aaa1578
• 发表时间: 2015-04-24
• 期刊: Science (New York, N.Y.)
• 作者: Ciancanelli MJ;Huang SX;Luthra P;Garner H;Itan Y;Volpi S;Lafaille FG;Trouillet C;Schmolke M;Albrecht RA;Israelsson E;Lim HK;Casadio M;Hermesh T;Lorenzo L;Leung LW;Pedergnana V;Boisson B;Okada S;Picard C;Ringuier B;Troussier F;Chaussabel D;Abel L;Pellier I;Notarangelo LD;García-Sastre A;Basler CF;Geissmann F;Zhang SY;Snoeck HW;Casanova JL
• 通讯作者: Casanova JL

新生児期の好中球減少症

新生儿中性粒细胞减少症

• 发表时间: 2014
• 作者: 岡田 賢;中村和洋;小林正夫
• 通讯作者: 小林正夫

Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.

• DOI: 10.1038/nature13801
• 发表时间: 2015-01-01
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Zhang, Xianqin;Bogunovic, Dusan;Payelle-Brogard, Beatrice;Francois-Newton, Veronique;Speer, Scott D.;Yuan, Chao;Volpi, Stefano;Li, Zhi;Sanal, Ozden;Mansouri, Davood;Tezcan, Ilhan;Rice, Gillian I.;Chen, Chunyuan;Mansouri, Nahal;Mahdaviani, Seyed Alireza;Itan, Yuval;Boisson, Bertrand;Okada, Satoshi;Zeng, Lu;Wang, Xing;Jiang, Hui;Liu, Wenqiang;Han, Tiantian;Liu, Delin;Ma, Tao;Wang, Bo;Liu, Mugen;Liu, Jing-Yu;Wang, Qing K.;Yalnizoglu, Dilek;Radoshevich, Lilliana;Uze, Gilles;Gros, Philippe;Rozenberg, Flore;Zhang, Shen-Ying;Jouanguy, Emmanuelle;Bustamante, Jacinta;Garcia-Sastre, Adolfo;Abel, Laurent;Lebon, Pierre;Notarangelo, Luigi D.;Crow, Yanick J.;Boisson-Dupuis, Stephanie;Casanova, Jean-Laurent;Pellegrini, Sandra
• 通讯作者: Pellegrini, Sandra

A novel homozygous p.R1105X mutation of the AP4E1 gene in twins with hereditary spastic paraplegia and mycobacterial disease.

• DOI: 10.1371/journal.pone.0058286
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kong XF;Bousfiha A;Rouissi A;Itan Y;Abhyankar A;Bryant V;Okada S;Ailal F;Bustamante J;Casanova JL;Hirst J;Boisson-Dupuis S
• 通讯作者: Boisson-Dupuis S

New and recurrent gain-of-function STAT1 mutations in patients with chronic mucocutaneous candidiasis from Eastern and Central Europe.

• DOI: 10.1136/jmedgenet-2013-101570
• 发表时间: 2013-09
• 期刊: Journal of medical genetics
• 影响因子: 4
• 作者: Soltész B;Tóth B;Shabashova N;Bondarenko A;Okada S;Cypowyj S;Abhyankar A;Csorba G;Taskó S;Sarkadi AK;Méhes L;Rozsíval P;Neumann D;Chernyshova L;Tulassay Z;Puel A;Casanova JL;Sediva A;Litzman J;Maródi L
• 通讯作者: Maródi L