Alternation of organ function in mice of jet-lag model

时差模型小鼠器官功能的变化

• 批准号: 25560426
• 负责人: OKAMURA Hitoshi
• 金额: $ 2.5万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25560426/
• 关键词: 脳とリズム; 時差; 生活習慣病; シフトワーク; 視交叉上核; 体重増加

Timed activities such as eating and sleeping are crucial for a comfortable social life and healthy living. As the living environment changes rapidly, and the numbers of around-the-clock facilities and people staying awake all night increase the convenience of consumers and the productivity of industries, the biological system to regulate our internal rhythms is being compromised. From screening the knockout of a variety of genes expressed in the SCN, here we identified the mice which do not show jet-lag even when they exposed suddenly to the 8-hour phase advance. We identified that the local circuits of vasopressin/V1aV1b-receptors in the SCN are crucial for jet-lag formation. From the analysis of chronic jet lag conditions, we want to clarify the mechanism of a life-style related disease evoked by chronic jet-lag.

诸如饮食和睡眠之类的定时活动对于舒适的社交生活和健康生活至关重要。随着生活环境的变化迅速，全天候设施的数量和整夜保持清醒的人的数量提高了消费者的便利性和行业的生产力，因此调节我们内部节奏的生物系统正在受到损害。从筛选在SCN中表达的各种基因的敲除，在这里，我们确定了小鼠，即使它们突然暴露于8小时的阶段前进时，它们也不会显示出喷射滞后。我们确定SCN中加压素/V1AV1B受体的局部电路对于喷射滞后形成至关重要。通过对慢性喷射滞后条件的分析，我们要阐明慢性喷气滞后引起的生活方式相关疾病的机制。

项目成果

New inter- and intracellular regulations of the circadian pacemaker

昼夜节律起搏器的新细胞间和细胞内调节

• 发表时间: 2014
• 作者: 河合美菜子;濱徳行;伊藤眞一;廣田秋彦;Hitoshi Okamura
• 通讯作者: Hitoshi Okamura

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

• DOI: 10.1016/j.cell.2013.10.026
• 发表时间: 2013-11-07
• 期刊: CELL
• 影响因子: 64.5
• 作者: Fustin, Jean-Michel;Doi, Masao;Okamura, Hitoshi
• 通讯作者: Okamura, Hitoshi

Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag

• DOI: 10.1126/science.1238599
• 发表时间: 2013-10-04
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Yamaguchi, Yoshiaki;Suzuki, Toru;Okamura, Hitoshi
• 通讯作者: Okamura, Hitoshi

クロノメタボリズム：時間相の医学生物学

时间代谢：时间阶段的医学生物学

• 发表时间: 2014
• 作者: Kawai M;Hama N;Ito S;Hirota A.;岡村均
• 通讯作者: 岡村均

New inter- and intracellular regulation of the circadian pacemaker

昼夜节律起搏器的新细胞间和细胞内调节

• 发表时间: 2014
• 作者: 中園智晶;高橋晋;櫻井芳雄;Okamura H
• 通讯作者: Okamura H