Alternation of organ function in mice of jet-lag model

时差模型小鼠器官功能的变化

• 批准号: 25560426
• 负责人: OKAMURA Hitoshi
• 金额: $ 2.5万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25560426/
• 关键词: 脳とリズム; 時差; 生活習慣病; シフトワーク; 視交叉上核; 体重増加

Timed activities such as eating and sleeping are crucial for a comfortable social life and healthy living. As the living environment changes rapidly, and the numbers of around-the-clock facilities and people staying awake all night increase the convenience of consumers and the productivity of industries, the biological system to regulate our internal rhythms is being compromised. From screening the knockout of a variety of genes expressed in the SCN, here we identified the mice which do not show jet-lag even when they exposed suddenly to the 8-hour phase advance. We identified that the local circuits of vasopressin/V1aV1b-receptors in the SCN are crucial for jet-lag formation. From the analysis of chronic jet lag conditions, we want to clarify the mechanism of a life-style related disease evoked by chronic jet-lag.

吃饭和睡觉等定时活动对于舒适的社交生活和健康的生活至关重要。随着生活环境的快速变化，全天候设施和彻夜不眠的人数增加了消费者的便利性和工业的生产力，调节我们内部节律的生物系统正在受到损害。通过筛选 SCN 中表达的多种基因的敲除，我们鉴定出即使突然暴露于 8 小时相位提前也不会表现出时差反应的小鼠。我们发现 SCN 中加压素/V1aV1b 受体的局部回路对于时差反应的形成至关重要。我们希望通过对慢性时差反应的分析，阐明慢性时差反应引发的生活方式相关疾病的机制。

项目成果

New inter- and intracellular regulations of the circadian pacemaker

昼夜节律起搏器的新细胞间和细胞内调节

• 发表时间: 2014
• 作者: 河合美菜子;濱徳行;伊藤眞一;廣田秋彦;Hitoshi Okamura
• 通讯作者: Hitoshi Okamura

Mice Genetically Deficient in Vasopressin V1a and V1b Receptors Are Resistant to Jet Lag

• DOI: 10.1126/science.1238599
• 发表时间: 2013-10-04
• 期刊: SCIENCE
• 影响因子: 56.9
• 作者: Yamaguchi, Yoshiaki;Suzuki, Toru;Okamura, Hitoshi
• 通讯作者: Okamura, Hitoshi

RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock

• DOI: 10.1016/j.cell.2013.10.026
• 发表时间: 2013-11-07
• 期刊: CELL
• 影响因子: 64.5
• 作者: Fustin, Jean-Michel;Doi, Masao;Okamura, Hitoshi
• 通讯作者: Okamura, Hitoshi

クロノメタボリズム：時間相の医学生物学

时间代谢：时间阶段的医学生物学

• 发表时间: 2014
• 作者: Kawai M;Hama N;Ito S;Hirota A.;岡村均
• 通讯作者: 岡村均

New inter- and intracellular regulation of the circadian pacemaker

昼夜节律起搏器的新细胞间和细胞内调节

• 发表时间: 2014
• 作者: 中園智晶;高橋晋;櫻井芳雄;Okamura H
• 通讯作者: Okamura H