Identification and functional analysis of the sensor system involved in behavioral regulation of larvae of digenic platyhelminthes.

双基因扁形动物幼虫行为调节涉及的传感器系统的识别和功能分析。

• 批准号: 23659209
• 负责人: OHTA Nobuo
• 金额: $ 2.41万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23659209/
• 关键词: 住血吸虫; セルカリア; 誘引行動; リノール酸; 認識センサー; RNA 干渉; マンソン住血吸虫; RNA干渉; センサー遺伝子

In the hope of uncovering sensor system of digenic platyhelminthes, we analyzed possible sensor organs of cercariae Schistosoma manosin. Cercariae of S. manosini were strongly attracted by linoleic acid and the responsible sensor seemed to be detected on the surface of cercariae. It was needed to test the direct effects of the probable sensors, and RNAi was applied for schistosoma cercariae. There are still technical matters left for RNAi at the cercarial stage. Results of the current study seem to lead development of reagents to avoid schistosomal infection targeting the skin penatration of cercariae.

为了揭示二含量铂螺旋的传感器系统，我们分析了cercariae cercariae slistosoma manosin的可能的传感器器官。马氏链球菌的cercariae被亚油酸强烈吸引，并且在cercariae的表面似乎检测到负责任的传感器。需要测试可能的传感器的直接效应，并将RNAi应用于cercariae。 RNAi在尾阶段仍然存在技术问题。当前研究的结果似乎导致试剂的开发，以避免针对尾膜皮肤的血吸虫感染。

项目成果

中国のOncomelania属貝と日本住血吸虫症の動向

中国钉螺和日本血吸虫病的流行趋势

• 发表时间: 2012
• 作者: 太田伸生;熊谷貴;陸紹紅;王天平;温礼永
• 通讯作者: 温礼永

Gene-knockdown against sporocysts from Schistosoma japonicum by RNAi

RNAi 对日本血吸虫孢子被的基因敲除

• 发表时间: 2013
• 作者: 岡本一男;小松紀子;高柳広;Takashi Kumagai
• 通讯作者: Takashi Kumagai

Effects of Mirazid in Schistosoma japonicum-infectedmice: parasitological and pathological assessment

米拉齐特对日本血吸虫感染小鼠的影响：寄生虫学和病理学评估

• 发表时间: 2012
• 期刊: Parasitol Res
• 影响因子: 2
• 作者: El-Malky MA;Lu SH;El-Bleshibishi SN;Saundy NS;Ohta N
• 通讯作者: Ohta N

Gene-knockdown against sporpcysts from Schistosoma japonicum by RNAi

RNAi 对日本血吸虫孢子囊的基因敲除

• 发表时间: 2013
• 作者: Kumagai T;Yamabe M;Seki T;Shimogawara R;Ohta N
• 通讯作者: Ohta N

CD36-related protein in Schistosoma japinicum: candidate mediator of selective cholesterol ester uptake from high-density lipoprotein for egg maturation.

日本血吸虫中的 CD36 相关蛋白：从高密度脂蛋白选择性摄取胆固醇酯以促进卵子成熟的候选介质。

• 发表时间: 2013
• 期刊: The FASEB Journal
• 作者: Okumura-Noji K;Miura Y;Lu R;Asai K;Ohta N;Brindley PJ;Yokoyama S;Kazuo Okamoto and Hiroshi Takayanagi;Kuniko Okumura-Noji
• 通讯作者: Kuniko Okumura-Noji